40S ribosomal protein S30

FAU
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2L7R,%%s4UG0, 4V6X, 5A2Q, 5AJ0, 5FLX
Identifiers
Aliases	FAU, FAU1, Fub1, Fubi, MNSFbeta, S30, asr1, Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed, ubiquitin like and ribosomal protein S30 fusion, FAU ubiquitin like and ribosomal protein S30 fusion, RPS30
External IDs	OMIM: 134690; MGI: 102547; HomoloGene: 37562; GeneCards: FAU; OMA:FAU - orthologs
Gene location (Human) Chr. Chromosome 11 (human) Band 11q13.1 Start 65,120,630 bp End 65,122,177 bp
Gene location (Mouse) Chr. Chromosome 19 (mouse) Band 19 A|19 4.34 cM Start 6,107,874 bp End 6,109,554 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte canal of the cervix left ovary monocyte amygdala right uterine tube tibial arteries muscle layer of sigmoid colon bone marrow cells right ovary Top expressed in spleen thymus urinary bladder bone marrow duodenum embryo embryo granulocyte jejunum yolk sac More reference expression data BioGPS n/a
Gene ontology Molecular function RNA binding structural constituent of ribosome Cellular component cellular component cytosol ribosome intracellular anatomical structure cytosolic small ribosomal subunit small ribosomal subunit nucleoplasm extracellular space Biological process biological process viral transcription SRP-dependent cotranslational protein targeting to membrane innate immune response in mucosa translational initiation nuclear-transcribed mRNA catabolic process, nonsense-mediated decay protein biosynthesis rRNA processing antimicrobial humoral immune response mediated by antimicrobial peptide Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2197 14109 Ensembl ENSG00000149806 ENSMUSG00000038274 UniProt P35544 P62861 P35545 P62862 RefSeq (mRNA) NM_001997 NM_001160239 NM_001190436 NM_007990 RefSeq (protein) NP_001988 NP_001153711 NP_001177365 NP_032016 Location (UCSC) Chr 11: 65.12 – 65.12 Mb Chr 19: 6.11 – 6.11 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

40S ribosomal protein S30 is a protein that in humans is encoded by the FAU gene.

Function

This gene is the cellular homolog of the fox sequence in the Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV). It encodes a fusion protein consisting of the ubiquitin-like protein fubi at the N-terminus and ribosomal protein S30 at the C-terminus. It has been proposed that the fusion protein is post-translationally processed to generate free fubi and free ribosomal protein S30. Fubi is a member of the ubiquitin family, and ribosomal protein S30 belongs to the S30E family of ribosomal proteins. Whereas the function of fubi is currently unknown, ribosomal protein S30 is a component of the 40S subunit of the cytoplasmic ribosome. Pseudogenes derived from this gene are present in the genome. Similar to ribosomal protein S30, ribosomal proteins S27a and L40 are synthesized as fusion proteins with ubiquitin.

Further reading

• Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–47. doi:10.1139/o95-101. PMID 8722009.
• Kas K, Michiels L, Merregaert J (1992). "Genomic structure and expression of the human fau gene: encoding the ribosomal protein S30 fused to a ubiquitin-like protein". Biochem. Biophys. Res. Commun. 187 (2): 927–33. doi:10.1016/0006-291X(92)91286-Y. PMID 1326960.
• Kato S, Sekine S, Oh SW, et al. (1995). "Construction of a human full-length cDNA bank". Gene. 150 (2): 243–50. doi:10.1016/0378-1119(94)90433-2. PMID 7821789.
• Michiels L, Van der Rauwelaert E, Van Hasselt F, et al. (1993). "fau cDNA encodes a ubiquitin-like-S30 fusion protein and is expressed as an antisense sequence in the Finkel-Biskis-Reilly murine sarcoma virus". Oncogene. 8 (9): 2537–46. PMID 8395683.
• Vladimirov SN, Ivanov AV, Karpova GG, et al. (1996). "Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry". Eur. J. Biochem. 239 (1): 144–9. doi:10.1111/j.1432-1033.1996.0144u.x. PMID 8706699.
• Kenmochi N, Kawaguchi T, Rozen S, et al. (1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Rossman TG, Visalli MA, Komissarova EV (2003). "fau and its ubiquitin-like domain (FUBI) transforms human osteogenic sarcoma (HOS) cells to anchorage-independence". Oncogene. 22 (12): 1817–21. doi:10.1038/sj.onc.1206283. PMID 12660817.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Mourtada-Maarabouni M, Kirkham L, Farzaneh F, Williams GT (2005). "Regulation of apoptosis by fau revealed by functional expression cloning and antisense expression". Oncogene. 23 (58): 9419–26. doi:10.1038/sj.onc.1208048. PMID 15543234.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
• Yu Y, Ji H, Doudna JA, Leary JA (2005). "Mass spectrometric analysis of the human 40S ribosomal subunit: native and HCV IRES-bound complexes". Protein Sci. 14 (6): 1438–46. doi:10.1110/ps.041293005. PMC 2253395. PMID 15883184.