FBXL5

FBXL5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3U9J, 3U9M, 3V5X, 3V5Y, 3V5Z
Identifiers
Aliases	FBXL5, FBL4, FBL5, FLR1, F-box and leucine-rich repeat protein 5, F-box and leucine rich repeat protein 5
External IDs	OMIM: 605655; MGI: 2152883; HomoloGene: 8129; GeneCards: FBXL5; OMA:FBXL5 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	15,681,679 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	43,978,980 bp
RNA expression pattern
	Top expressed in
	monocyte; ; Epithelium of choroid plexus; ; Achilles tendon; ; kidney tubule; ; blood; ; seminal vesicula; ; germinal epithelium; ; oocyte; ; secondary oocyte; ; sperm;
	Top expressed in
	spermatocyte; ; granulocyte; ; otolith organ; ; utricle; ; spermatid; ; neural layer of retina; ; lobe of cerebellum; ; gastrula; ; cerebellar vermis; ; habenula;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	iron ion binding; protein binding; metal ion binding; ubiquitin-protein transferase activity;
Cellular component	ubiquitin ligase complex; cytoplasm; SCF ubiquitin ligase complex; perinuclear region of cytoplasm; cytosol;
Biological process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination; iron ion homeostasis; protein polyubiquitination; cellular iron ion homeostasis; post-translational protein modification; ubiquitin-dependent protein catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	26234
	242960
	ENSG00000118564
	ENSMUSG00000039753
	Q9UKA1
	Q8C2S5
	NM_001193534; NM_001193535; NM_012161
	NM_001159963; NM_178729
	NP_001180463; NP_001180464; NP_036293
	NP_001153435; NP_848844
	Wikidata
View/Edit Human	View/Edit Mouse

F-box/LRR-repeat protein 5 is a protein that in humans is encoded by the FBXL5 gene.^[5]^[6]

Template:PBB Summary

FBXL5 is an iron sensor. It promotes IRP2 ubiquitination and then its degradation.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000118564 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000039753 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (Dec 1999). "Identification of a family of human F-box proteins". Curr Biol. 9 (20): 1177–9. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035.
^ "Entrez Gene: FBXL5 F-box and leucine-rich repeat protein 5".

References

Further reading