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FBXW10

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FBXW10
Identifiers
AliasesFBXW10, Fbw10, HREP, SM25H2, SM2SH2, F-box and WD repeat domain containing 10
External IDsOMIM: 611679; MGI: 3052463; HomoloGene: 32757; GeneCards: FBXW10; OMA:FBXW10 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001267585
NM_001267586
NM_031456

NM_001033669
NM_001291441

RefSeq (protein)

NP_001254514
NP_001254515

Location (UCSC)Chr 17: 18.74 – 18.78 MbChr 11: 62.74 – 62.77 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

F-box/WD repeat-containing protein 10 is a protein that in humans is encoded by the FBXW10 gene.[5][6][7]

Members of the F-box protein family, such as FBXW10, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603034), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004).[supplied by OMIM][7] Increased expression of the gene has been associated with laminopathies, and in degradation of chromatin associated proteins such as HP1, ATR kinases (Chaturvedi and ParnaiK, 2010, PMID 20498703).


References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000171931Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000090173Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kennerson ML, Nassif NT, Nicholson GA (Dec 1998). "Genomic structure and physical mapping of C17orf1: a gene associated with the proximal element of the CMT1A-REP binary repeat". Genomics. 53 (1): 110–2. doi:10.1006/geno.1998.5453. PMID 9787083.
  6. ^ Kennerson ML, Gordon MJ, Blair IP, Nicholson GA (Dec 1995). "Single test for two hereditary neuropathies, CMT1A and HNPP". Clin Chem. 41 (10): 1534–5. doi:10.1093/clinchem/41.10.1534. PMID 7586531.
  7. ^ a b "Entrez Gene: FBXW10 F-box and WD repeat domain containing 10".

Further reading

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