FEZ1

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FEZ1
Identifiers
Aliases FEZ1, UNC-76, fasciculation and elongation protein zeta 1
External IDs MGI: 2670976 HomoloGene: 21063 GeneCards: FEZ1
RNA expression pattern
PBB GE FEZ1 203562 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005103
NM_022549

NM_183171

RefSeq (protein)

NP_005094
NP_072043

NP_898994.2

Location (UCSC) Chr 11: 125.45 – 125.5 Mb Chr 9: 36.82 – 36.88 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Fasciculation and elongation protein zeta-1 is a protein that in humans is encoded by the FEZ1 gene.[3][4][5]

This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Expression of this gene in C. elegans unc-76 mutants can restore to the mutants partial locomotion and axonal fasciculation, suggesting that it also functions in axonal outgrowth. The N-terminal half of the gene product is highly acidic. Alternatively spliced transcript variants encoding different isoforms of this protein have been described.[5]

This protein is present in neurons, and it is believed to block the process of infection of these cells by HIV.[6]

Interactions[edit]

FEZ1 has been shown to interact with Protein kinase Mζ,[7] NBR1[8] and DISC1.[9]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Bloom L, Horvitz HR (May 1997). "The Caenorhabditis elegans gene unc-76 and its human homologs define a new gene family involved in axonal outgrowth and fasciculation". Proc Natl Acad Sci U S A. 94 (7): 3414–9. Bibcode:1997PNAS...94.3414B. doi:10.1073/pnas.94.7.3414. PMC 20384Freely accessible. PMID 9096408. 
  4. ^ Suzuki T, Okada Y, Semba S, Orba Y, Yamanouchi S, Endo S, Tanaka S, Fujita T, Kuroda S, Nagashima K, Sawa H (Jun 2005). "Identification of FEZ1 as a protein that interacts with JC virus agnoprotein and microtubules: role of agnoprotein-induced dissociation of FEZ1 from microtubules in viral propagation". J Biol Chem. 280 (26): 24948–56. doi:10.1074/jbc.M411499200. PMID 15843383. 
  5. ^ a b "Entrez Gene: FEZ1 fasciculation and elongation protein zeta 1 (zygin I)". 
  6. ^ Haedicke, J.; Brown, C.; Naghavi, M. H. (Aug 2009). "The brain-specific factor FEZ1 is a determinant of neuronal susceptibility to HIV-1 infection". Proceedings of the National Academy of Sciences. 106 (33): 14040–14045. Bibcode:2009PNAS..10614040H. doi:10.1073/pnas.0900502106. ISSN 0027-8424. PMC 2729016Freely accessible. PMID 19667186. 
  7. ^ Kuroda, S; Nakagawa N; Tokunaga C; Tatematsu K; Tanizawa K (Feb 1999). "Mammalian homologue of the Caenorhabditis elegans UNC-76 protein involved in axonal outgrowth is a protein kinase C zeta-interacting protein". J. Cell Biol. UNITED STATES. 144 (3): 403–11. doi:10.1083/jcb.144.3.403. ISSN 0021-9525. PMC 2132904Freely accessible. PMID 9971736. 
  8. ^ Whitehouse, Caroline; Chambers Julie; Howe Kathy; Cobourne Martyn; Sharpe Paul; Solomon Ellen (Jan 2002). "NBR1 interacts with fasciculation and elongation protein zeta-1 (FEZ1) and calcium and integrin binding protein (CIB) and shows developmentally restricted expression in the neural tube". Eur. J. Biochem. Germany. 269 (2): 538–45. doi:10.1046/j.0014-2956.2001.02681.x. ISSN 0014-2956. PMID 11856312. 
  9. ^ Miyoshi, K; Honda A; Baba K; Taniguchi M; Oono K; Fujita T; Kuroda S; Katayama T; Tohyama M (Jul 2003). "Disrupted-In-Schizophrenia 1, a candidate gene for schizophrenia, participates in neurite outgrowth". Mol. Psychiatry. England. 8 (7): 685–94. doi:10.1038/sj.mp.4001352. ISSN 1359-4184. PMID 12874605. 

Further reading[edit]