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AliasesFEZ1, UNC-76, fasciculation and elongation protein zeta 1
External IDsMGI: 2670976 HomoloGene: 21063 GeneCards: FEZ1
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for FEZ1
Genomic location for FEZ1
Band11q24.2Start125,442,881 bp[1]
End125,592,568 bp[1]
RNA expression pattern
PBB GE FEZ1 203562 at fs.png
More reference expression data
RefSeq (mRNA)


RefSeq (protein)


Location (UCSC)Chr 11: 125.44 – 125.59 MbChr 9: 36.82 – 36.88 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Fasciculation and elongation protein zeta-1 is a protein that in humans is encoded by the FEZ1 gene.[5][6][7]

This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Expression of this gene in C. elegans unc-76 mutants can restore to the mutants partial locomotion and axonal fasciculation, suggesting that it also functions in axonal outgrowth. The N-terminal half of the gene product is highly acidic. Alternatively spliced transcript variants encoding different isoforms of this protein have been described.[7]

This protein is present in neurons, and it is believed to block the process of infection of these cells by HIV.[8]


FEZ1 has been shown to interact with Protein kinase Mζ,[9] NBR1[10] and DISC1.[11]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000149557 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032118 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Bloom L, Horvitz HR (May 1997). "The Caenorhabditis elegans gene unc-76 and its human homologs define a new gene family involved in axonal outgrowth and fasciculation". Proc Natl Acad Sci U S A. 94 (7): 3414–9. Bibcode:1997PNAS...94.3414B. doi:10.1073/pnas.94.7.3414. PMC 20384. PMID 9096408.
  6. ^ Suzuki T, Okada Y, Semba S, Orba Y, Yamanouchi S, Endo S, Tanaka S, Fujita T, Kuroda S, Nagashima K, Sawa H (Jun 2005). "Identification of FEZ1 as a protein that interacts with JC virus agnoprotein and microtubules: role of agnoprotein-induced dissociation of FEZ1 from microtubules in viral propagation". J Biol Chem. 280 (26): 24948–56. doi:10.1074/jbc.M411499200. PMID 15843383.
  7. ^ a b "Entrez Gene: FEZ1 fasciculation and elongation protein zeta 1 (zygin I)".
  8. ^ Haedicke, J.; Brown, C.; Naghavi, M. H. (Aug 2009). "The brain-specific factor FEZ1 is a determinant of neuronal susceptibility to HIV-1 infection". Proceedings of the National Academy of Sciences. 106 (33): 14040–14045. Bibcode:2009PNAS..10614040H. doi:10.1073/pnas.0900502106. ISSN 0027-8424. PMC 2729016. PMID 19667186.
  9. ^ Kuroda, S; Nakagawa N; Tokunaga C; Tatematsu K; Tanizawa K (Feb 1999). "Mammalian homologue of the Caenorhabditis elegans UNC-76 protein involved in axonal outgrowth is a protein kinase C zeta-interacting protein". J. Cell Biol. 144 (3): 403–11. doi:10.1083/jcb.144.3.403. ISSN 0021-9525. PMC 2132904. PMID 9971736.
  10. ^ Whitehouse, Caroline; Chambers Julie; Howe Kathy; Cobourne Martyn; Sharpe Paul; Solomon Ellen (Jan 2002). "NBR1 interacts with fasciculation and elongation protein zeta-1 (FEZ1) and calcium and integrin binding protein (CIB) and shows developmentally restricted expression in the neural tube". Eur. J. Biochem. 269 (2): 538–45. doi:10.1046/j.0014-2956.2001.02681.x. ISSN 0014-2956. PMID 11856312.
  11. ^ Miyoshi, K; Honda A; Baba K; Taniguchi M; Oono K; Fujita T; Kuroda S; Katayama T; Tohyama M (Jul 2003). "Disrupted-In-Schizophrenia 1, a candidate gene for schizophrenia, participates in neurite outgrowth". Mol. Psychiatry. 8 (7): 685–94. doi:10.1038/sj.mp.4001352. ISSN 1359-4184. PMID 12874605.

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