NBR1

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NBR1
Protein NBR1 PDB 1wj6.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases NBR1, 1A1-3B, IAI3B, M17S2, MIG19, neighbor of BRCA1 gene 1, autophagy cargo receptor
External IDs MGI: 108498 HomoloGene: 7438 GeneCards: NBR1
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001291571
NM_001291572
NM_005899
NM_031858
NM_031862

NM_001252220
NM_001252222
NM_001252223
NM_008676

RefSeq (protein)

NP_001278500
NP_001278501
NP_005890
NP_114068

Location (UCSC) Chr 17: 43.17 – 43.21 Mb Chr 11: 101.55 – 101.58 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Neighbor of BRCA1 gene 1 protein is a protein that in humans is encoded by the NBR1 gene.[3][4]

The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled coil motif, which is present in many genes with transformation potential. This gene is located on a region of chromosome 17q21.1 that is in close proximity to tumor suppressor gene BRCA1. Three alternatively spliced variants encoding the same protein have been identified for this gene.[4] One implied function lies in autophagy, where it acts a cargo receptor in selective autophagy.[5]

Interactions[edit]

NBR1 has been shown to interact with FEZ1.[6]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Campbell IG, Nicolai HM, Foulkes WD, Senger G, Stamp GW, Allan G, Boyer C, Jones K, Bast RC Jr, Solomon E (Sep 1994). "A novel gene encoding a B-box protein within the BRCA1 region at 17q21.1". Hum Mol Genet. 3 (4): 589–594. doi:10.1093/hmg/3.4.589. PMID 8069304. 
  4. ^ a b "Entrez Gene: NBR1 neighbor of BRCA1 gene 1". 
  5. ^ Kirkin, Vladimir (2009). "A Role for Ubiquitin in Selective Autophagy". Molecular Cell. 34: 259–269. doi:10.1016/j.molcel.2009.04.026. 
  6. ^ Whitehouse, Caroline; Chambers Julie; Howe Kathy; Cobourne Martyn; Sharpe Paul; Solomon Ellen (Jan 2002). "NBR1 interacts with fasciculation and elongation protein zeta-1 (FEZ1) and calcium and integrin binding protein (CIB) and shows developmentally restricted expression in the neural tube". Eur. J. Biochem. Germany. 269 (2): 538–545. doi:10.1046/j.0014-2956.2001.02681.x. ISSN 0014-2956. PMID 11856312. 

Further reading[edit]