FLII

FLII
Identifiers
Aliases	FLII, FLI, FLIL, Fli1, actin remodeling protein, FLII actin remodeling protein
External IDs	OMIM: 600362; MGI: 1342286; HomoloGene: 11092; GeneCards: FLII; OMA:FLII - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	18,258,738 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	60,618,089 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; muscle of thigh; ; gastrocnemius muscle; ; skeletal muscle tissue; ; spleen; ; mucosa of transverse colon; ; pituitary gland; ; anterior pituitary; ; minor salivary glands; ; right lobe of thyroid gland;
	Top expressed in
	Ileal epithelium; ; choroid plexus of fourth ventricle; ; granulocyte; ; cardiac muscle tissue of left ventricle; ; lactiferous gland; ; tracheobronchial tree; ; internal carotid artery; ; mesenteric lymph nodes; ; right lung lobe; ; muscle of thigh;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	actin binding; protein binding; actin filament binding;
Cellular component	cell junction; cytoskeleton; brush border; nucleus; focal adhesion; nucleoplasm; microtubule organizing center; cytoplasm; cytosol;
Biological process	multicellular organism development; actin filament severing; regulation of transcription, DNA-templated; actin cytoskeleton organization; transcription, DNA-templated;
	Sources:Amigo / QuickGO
Orthologs
	2314
	14248
	ENSG00000177731; ENSG00000284571
	ENSMUSG00000002812
	Q13045
	Q9JJ28
	NM_001256264; NM_001256265; NM_002018
	NM_022009; NM_001302207
	NP_001243193; NP_001243194; NP_002009
	NP_001289136; NP_071292
	Wikidata
View/Edit Human	View/Edit Mouse

Protein flightless-1 homolog is a protein that in humans is encoded by the FLII gene.^[5]^[6]

Template:PBB Summary

Interactions

FLII has been shown to interact with LRRFIP1^[7]^[8] and TRAF interacting protein.^[9]

References

^ ^a ^b ^c ENSG00000284571 GRCh38: Ensembl release 89: ENSG00000177731, ENSG00000284571 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000002812 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Chen KS, Gunaratne PH, Hoheisel JD, Young IG, Miklos GL, Greenberg F, Shaffer LG, Campbell HD, Lupski JR (Feb 1995). "The human homologue of the Drosophila melanogaster flightless-I gene (flil) maps within the Smith-Magenis microdeletion critical region in 17p11.2". Am J Hum Genet. 56 (1): 175–82. PMC 1801336. PMID 7825574.
^ "Entrez Gene: FLII flightless I homolog (Drosophila)".
^ Liu, Y T; Yin H L (Apr 1998). "Identification of the binding partners for flightless I, A novel protein bridging the leucine-rich repeat and the gelsolin superfamilies". J. Biol. Chem. 273 (14). UNITED STATES: 7920–7. doi:10.1074/jbc.273.14.7920. ISSN 0021-9258. PMID 9525888. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help)CS1 maint: unflagged free DOI (link)
^ Fong, K S; de Couet H G (Jun 1999). "Novel proteins interacting with the leucine-rich repeat domain of human flightless-I identified by the yeast two-hybrid system". Genomics. 58 (2). UNITED STATES: 146–57. doi:10.1006/geno.1999.5817. ISSN 0888-7543. PMID 10366446. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help)
^ Wilson, S A; Brown E C; Kingsman A J; Kingsman S M (Aug 1998). "TRIP: a novel double stranded RNA binding protein which interacts with the leucine rich repeat of flightless I". Nucleic Acids Res. 26 (15). ENGLAND: 3460–7. doi:10.1093/nar/26.15.3460. ISSN 0305-1048. PMC 147727. PMID 9671805. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)

Interactions

References

Further reading