FNTA

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FNTA
Protein FNTA PDB 1d8d.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases FNTA, FPTA, PGGT1A, PTAR2, farnesyltransferase, CAAX box, alpha
External IDs MGI: 104683 HomoloGene: 1534 GeneCards: FNTA
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001018676
NM_001018677
NM_002027

NM_008033

RefSeq (protein)

NP_002018

NP_032059.1
NP_032059

Location (UCSC) Chr 8: 43.03 – 43.09 Mb Chr 8: 26 – 26.02 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha is an enzyme that in humans is encoded by the FNTA gene.[3][4]

Prenyltransferases attach either a farnesyl group or a geranylgeranyl group in thioether linkage to the cysteine residue of protein's with a C-terminal CAAX box. CAAX geranylgeranyltransferase and CAAX farnesyltransferase are heterodimers that share the same alpha subunit but have different beta subunits. This gene encodes the alpha subunit of these transferases. Alternative splicing results in multiple transcript variants encoding different isoforms.[4]

Interactions[edit]

FNTA has been shown to interact with TGF beta receptor 1.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Andres DA, Milatovich A, Ozcelik T, Wenzlau JM, Brown MS, Goldstein JL, Francke U (February 1994). "cDNA cloning of the two subunits of human CAAX farnesyltransferase and chromosomal mapping of FNTA and FNTB loci and related sequences". Genomics. 18 (1): 105–12. doi:10.1006/geno.1993.1432. PMID 8276393. 
  4. ^ a b "Entrez Gene: FNTA farnesyltransferase, CAAX box, alpha". 
  5. ^ Kawabata, M; Imamura T; Miyazono K; Engel M E; Moses H L (December 1995). "Interaction of the transforming growth factor-beta type I receptor with farnesyl-protein transferase-alpha". J. Biol. Chem. UNITED STATES. 270 (50): 29628–31. doi:10.1074/jbc.270.50.29628. ISSN 0021-9258. PMID 8530343. 

Further reading[edit]