FRAT2

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FRAT2
Identifiers
Aliases FRAT2
External IDs MGI: 2673967 HomoloGene: 8095 GeneCards: FRAT2
RNA expression pattern
PBB GE FRAT2 209864 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_012083

NM_177603

RefSeq (protein)

NP_036215

NP_808271.1
NP_808271

Location (UCSC) Chr 10: 97.33 – 97.33 Mb Chr 19: 41.85 – 41.85 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

GSK-3-binding protein FRAT2 is a protein that in humans is encoded by the FRAT2 gene.[3][4][5]

The protein encoded by this intronless gene belongs to the GSK-3-binding protein family. Studies show that this protein plays a role as a positive regulator of the WNT signaling pathway. It may be upregulated in tumor progression.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Yost C, Farr GH 3rd, Pierce SB, Ferkey DM, Chen MM, Kimelman D (Jul 1998). "GBP, an inhibitor of GSK-3, is implicated in Xenopus development and oncogenesis". Cell. 93 (6): 1031–41. doi:10.1016/S0092-8674(00)81208-8. PMID 9635432. 
  4. ^ Saitoh T, Moriwaki J, Koike J, Takagi A, Miwa T, Shiokawa K, Katoh M (Mar 2001). "Molecular cloning and characterization of FRAT2, encoding a positive regulator of the WNT signaling pathway". Biochem Biophys Res Commun. 281 (3): 815–20. doi:10.1006/bbrc.2001.4421. PMID 11237732. 
  5. ^ a b "Entrez Gene: FRAT2 frequently rearranged in advanced T-cell lymphomas 2". 

Further reading[edit]