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Available structures
PDB Ortholog search: PDBe RCSB
Aliases FZR1, CDC20C, CDH1, FZR, FZR2, HCDH, HCDH1, fizzy/cell division cycle 20 related 1, fizzy and cell division cycle 20 related 1
External IDs MGI: 1926790 HomoloGene: 9444 GeneCards: FZR1
Gene location (Human)
Chromosome 19 (human)
Chr. Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for FZR1
Genomic location for FZR1
Band 19p13.3 Start 3,506,273 bp[1]
End 3,538,330 bp[1]
RNA expression pattern
PBB GE FZR1 209414 at fs.png

PBB GE FZR1 209416 s at fs.png

PBB GE FZR1 209415 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 19: 3.51 – 3.54 Mb Chr 10: 81.37 – 81.38 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Fizzy-related protein homolog is a protein that in humans is encoded by the FZR1 gene.[5][6][7]


FZR1 has been shown to interact with CDC27[8][9] and FBXO5.[10]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000105325 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020235 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Fang G, Yu H, Kirschner MW (Sep 1998). "Direct binding of CDC20 protein family members activates the anaphase-promoting complex in mitosis and G1". Mol Cell. 2 (2): 163–171. doi:10.1016/S1097-2765(00)80126-4. PMID 9734353. 
  6. ^ Sorensen CS, Lukas C, Kramer ER, Peters JM, Bartek J, Lukas J (Oct 2000). "Nonperiodic activity of the human anaphase-promoting complex-Cdh1 ubiquitin ligase results in continuous DNA synthesis uncoupled from mitosis". Mol Cell Biol. 20 (20): 7613–7623. doi:10.1128/MCB.20.20.7613-7623.2000. PMC 86321Freely accessible. PMID 11003657. 
  7. ^ "Entrez Gene: FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)". 
  8. ^ Zhou, Yuan; Ching Yick-Pang; Ng Raymond W M; Jin Dong-Yan (Sep 2003). "Differential expression, localization and activity of two alternatively spliced isoforms of human APC regulator CDH1". Biochem. J. England. 374 (Pt 2): 349–58. doi:10.1042/BJ20030600. PMC 1223613Freely accessible. PMID 12797865. 
  9. ^ Kramer, E R; Gieffers C; Hölzl G; Hengstschläger M; Peters J M (Nov 1998). "Activation of the human anaphase-promoting complex by proteins of the CDC20/Fizzy family". Curr. Biol. ENGLAND. 8 (22): 1207–S4. doi:10.1016/S0960-9822(07)00510-6. ISSN 0960-9822. PMID 9811605. 
  10. ^ Hsu, Jerry Y; Reimann Julie D R; Sørensen Claus S; Lukas Jiri; Jackson Peter K (May 2002). "E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1)". Nat. Cell Biol. England. 4 (5): 358–366. doi:10.1038/ncb785. ISSN 1465-7392. PMID 11988738. 

Further reading[edit]