FZR1

FZR1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4UI9
Identifiers
Aliases	FZR1, CDC20C, CDH1, FZR, FZR2, HCDH, HCDH1, fizzy/cell division cycle 20 related 1, fizzy and cell division cycle 20 related 1
External IDs	OMIM: 603619; MGI: 1926790; HomoloGene: 9444; GeneCards: FZR1; OMA:FZR1 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	3,538,334 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	81,214,350 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; left testis; ; right testis; ; sural nerve; ; anterior pituitary; ; ganglionic eminence; ; skin of leg; ; right hemisphere of cerebellum; ; tendon of biceps brachii; ; stromal cell of endometrium;
	Top expressed in
	spermatid; ; seminiferous tubule; ; ventricular zone; ; spermatocyte; ; interventricular septum; ; yolk sac; ; fetal liver hematopoietic progenitor cell; ; dentate gyrus of hippocampal formation granule cell; ; neural tube; ; primary visual cortex;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; anaphase-promoting complex binding; ubiquitin-protein transferase activator activity;
Cellular component	cytoplasm; cytosol; nuclear membrane; nucleoplasm; anaphase-promoting complex; nucleus;
Biological process	positive regulation of protein catabolic process; regulation of meiotic nuclear division; cellular response to DNA damage stimulus; cell division; protein K11-linked ubiquitination; lens fiber cell differentiation; protein ubiquitination; positive regulation of cell population proliferation; cell cycle; anaphase-promoting complex-dependent catabolic process; DNA repair; positive regulation of ubiquitin protein ligase activity; mitotic G2 DNA damage checkpoint signaling; regulation of mitotic cell cycle phase transition; ubiquitin-dependent protein catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	51343
	56371
	ENSG00000105325
	ENSMUSG00000020235
	Q9UM11
	Q9R1K5
	NM_001136197; NM_001136198; NM_016263
	NM_019757
	NP_001129669; NP_001129670; NP_057347
	NP_062731
	Wikidata
View/Edit Human	View/Edit Mouse

Fizzy-related protein homolog is a protein that in humans is encoded by the FZR1 gene.^[5]^[6]^[7] Template:PBB Summary

Interactions

FZR1 has been shown to interact with CDC27^[8]^[9] and FBXO5.^[10]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000105325 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020235 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Fang G, Yu H, Kirschner MW (Sep 1998). "Direct binding of CDC20 protein family members activates the anaphase-promoting complex in mitosis and G1". Mol Cell. 2 (2): 163–171. doi:10.1016/S1097-2765(00)80126-4. PMID 9734353.
^ Sorensen CS, Lukas C, Kramer ER, Peters JM, Bartek J, Lukas J (Oct 2000). "Nonperiodic activity of the human anaphase-promoting complex-Cdh1 ubiquitin ligase results in continuous DNA synthesis uncoupled from mitosis". Mol Cell Biol. 20 (20): 7613–7623. doi:10.1128/MCB.20.20.7613-7623.2000. PMC 86321. PMID 11003657.
^ "Entrez Gene: FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)".
^ Zhou, Yuan; Ching Yick-Pang; Ng Raymond W M; Jin Dong-Yan (Sep 2003). "Differential expression, localization and activity of two alternatively spliced isoforms of human APC regulator CDH1". Biochem. J. 374 (Pt 2). England: 349–58. doi:10.1042/BJ20030600. PMC 1223613. PMID 12797865.
^ Kramer, E R; Gieffers C; Hölzl G; Hengstschläger M; Peters J M (Nov 1998). "Activation of the human anaphase-promoting complex by proteins of the CDC20/Fizzy family". Curr. Biol. 8 (22). ENGLAND: 1207–S4. doi:10.1016/S0960-9822(07)00510-6. ISSN 0960-9822. PMID 9811605.
^ Hsu, Jerry Y; Reimann Julie D R; Sørensen Claus S; Lukas Jiri; Jackson Peter K (May 2002). "E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1)". Nat. Cell Biol. 4 (5). England: 358–366. doi:10.1038/ncb785. ISSN 1465-7392. PMID 11988738.

Interactions

References

Further reading