Flavin prenyltransferase

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flavin prenyltransferase
4zaf.jpg
Flavin prenyltransferase homododekamer, Pseudomonas aeruginosa
Identifiers
EC number2.5.1.129
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

Flavin prenyltransferase EC 2.5.1.129 UbiX, that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN)[1] for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.

Catalytic activity:

Dimethylallyl phosphate + FMNH2 prenylated FMNH2 + phosphate.

References[edit]

  1. ^ White, M.D.; Payne, K. A.; Fisher, K.; Marshall, S .A.; Parker, D.; et al. (2015). "UbiX is a flavin prenyltransferase required for bacterial ubiquinone biosynthesis". Nature. 522: 502–506. PMID 26083743.