Foreign body granuloma

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Foreign body granuloma
Perforated IUD.jpg
Transvaginal ultrasonography showing a foreign body granuloma at right as a hypoechoic (dark) area around a perforated intrauterine device. The uterus is at left.
Classification and external resources
Specialty dermatology
ICD-10 L92.3 (ILDS L92.300)
A foreign-body response to talc (talcosis) due to intravenous drug use. H&E stain.

The foreign body granuloma is a response of biological tissue to any foreign material in the tissue.[1] Tissue-encapsulation of an implant is part of this. An infection around a splinter is part of this, too.[2]

The presence of the implant changes the healing response, and this is called the foreign-body reaction (FBR). FBR consists of: protein adsorption, macrophages, multinucleated foreign body giant cells (macrophage fusion), fibroblasts, and angiogenesis.

It can be caused by beryllium.[3]

See also[edit]


  1. ^ Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. p. 1443. ISBN 1-4160-2999-0. 
  2. ^ Biomaterials Science Second edition, Ratner et al. Pp. 296-304
  3. ^ Haley PJ (1991). "Mechanisms of granulomatous lung disease from inhaled beryllium: the role of antigenicity in granuloma formation". Toxicologic pathology. 19 (4 Pt 1): 514–25. PMID 1813991. doi:10.1177/019262339101900417.