GGA1

GGA1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1J2J, 1JWF, 1JWG, 1NA8, 1NAF, 1NWM, 1O3X, 1OM9, 1OXZ, 1PY1, 1UJJ, 1UJK, 1X79, 2DWX, 2DWY, 3G2S, 3G2T, 3G2U, 3G2V, 3G2W
Identifiers
Aliases	GGA1, golgi associated, gamma adaptin ear containing, ARF binding protein 1
External IDs	OMIM: 606004; MGI: 2146207; HomoloGene: 39250; GeneCards: GGA1; OMA:GGA1 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	37,633,564 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	78,778,785 bp
RNA expression pattern
	Top expressed in
	pancreatic ductal cell; ; left testis; ; right testis; ; endothelial cell; ; right uterine tube; ; mucosa of ileum; ; right hemisphere of cerebellum; ; pituitary gland; ; gingival epithelium; ; anterior pituitary;
	Top expressed in
	granulocyte; ; muscle of thigh; ; lip; ; pyloric antrum; ; yolk sac; ; superior frontal gyrus; ; ventricular zone; ; dentate gyrus of hippocampal formation granule cell; ; primary visual cortex; ; esophagus;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; protein heterodimerization activity; molecular function;
Cellular component	endosome; Golgi apparatus; endosome membrane; intracellular anatomical structure; membrane; intracellular membrane-bounded organelle; clathrin adaptor complex; nucleoplasm; early endosome membrane; early endosome; cytosol; protein-containing complex;
Biological process	protein transport; intracellular protein transport; toxin transport; positive regulation of protein catabolic process; vesicle-mediated transport; transport; Golgi to plasma membrane transport; protein localization; protein localization to cell surface; retrograde transport, endosome to Golgi; Golgi to plasma membrane protein transport; protein localization to ciliary membrane;
	Sources:Amigo / QuickGO
Orthologs
	26088
	106039
	ENSG00000100083
	ENSMUSG00000033128
	Q9UJY5
	Q8R0H9
NM_001001560; NM_001001561; NM_001172687; NM_001172688; NM_013365;
	NM_001363771
	NM_145929
	NP_001001560; NP_001166158; NP_001166159; NP_037497; NP_001350700
	NP_666041
	Wikidata
View/Edit Human	View/Edit Mouse

ADP-ribosylation factor-binding protein GGA1 is a protein that in humans is encoded by the GGA1 gene.^[5]^[6]^[7]

Template:PBB Summary

Interactions

GGA1 has been shown to interact with Sortilin 1,^[8] BACE2,^[9] RABEP1^[10] and ARF3.^[11]^[12]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000100083 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000033128 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hirst J, Lui WW, Bright NA, Totty N, Seaman MN, Robinson MS (May 2000). "A family of proteins with gamma-adaptin and VHS domains that facilitate trafficking between the trans-Golgi network and the vacuole/lysosome". J Cell Biol. 149 (1): 67–80. doi:10.1083/jcb.149.1.67. PMC 2175106. PMID 10747088.
^ Dell'Angelica EC, Puertollano R, Mullins C, Aguilar RC, Vargas JD, Hartnell LM, Bonifacino JS (May 2000). "GGAs: a family of ADP ribosylation factor-binding proteins related to adaptors and associated with the Golgi complex". J Cell Biol. 149 (1): 81–94. doi:10.1083/jcb.149.1.81. PMC 2175099. PMID 10747089.
^ Xie L, Boyle D, Sanford D, Scherer PE, Pessin JE, Mora S (March 2006). "Intracellular trafficking and secretion of adiponectin is dependent on GGA-coated vesicles". J Biol Chem. 281 (11): 7253–9. doi:10.1074/jbc.M511313200. PMID 16407204.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ Jacobsen, Linda; Madsen Peder; Nielsen Morten S; Geraerts Wijnand P M; Gliemann Jørgen; Smit August B; Petersen Claus M (January 2002). "The sorLA cytoplasmic domain interacts with GGA1 and -2 and defines minimum requirements for GGA binding". FEBS Lett. 511 (1–3). Netherlands: 155–8. doi:10.1016/S0014-5793(01)03299-9. ISSN 0014-5793. PMID 11821067. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)
^ He, Xiangyuan; Chang Wan-Pin; Koelsch Gerald; Tang Jordan (July 2002). "Memapsin 2 (beta-secretase) cytosolic domain binds to the VHS domains of GGA1 and GGA2: implications on the endocytosis mechanism of memapsin 2". FEBS Lett. 524 (1–3). Netherlands: 183–7. doi:10.1016/S0014-5793(02)03052-1. ISSN 0014-5793. PMID 12135764. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)
^ Mattera, Rafael; Arighi Cecilia N; Lodge Robert; Zerial Marino; Bonifacino Juan S (January 2003). "Divalent interaction of the GGAs with the Rabaptin-5-Rabex-5 complex". EMBO J. 22 (1). England: 78–88. doi:10.1093/emboj/cdg015. ISSN 0261-4189. PMC 140067. PMID 12505986. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)
^ Boman, Annette L; Salo Paul D; Hauglund Melissa J; Strand Nicole L; Rensink Shelly J; Zhdankina Olga (September 2002). "ADP-ribosylation factor (ARF) interaction is not sufficient for yeast GGA protein function or localization". Mol. Biol. Cell. 13 (9). United States: 3078–95. doi:10.1091/mbc.E02-02-0078. ISSN 1059-1524. PMC 124144. PMID 12221117. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)
^ Boman, A L; Zhang C j; Zhu X; Kahn R A (April 2000). "A family of ADP-ribosylation factor effectors that can alter membrane transport through the trans-Golgi". Mol. Biol. Cell. 11 (4). UNITED STATES: 1241–55. doi:10.1091/mbc.11.4.1241. ISSN 1059-1524. PMC 14844. PMID 10749927. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)

Interactions

References

Further reading