GGPS1

GGPS1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2Q80
Identifiers
Aliases	GGPS1, GGPPS, GGPPS1, geranylgeranyl diphosphate synthase 1, MDHLO, MUDHLOV
External IDs	OMIM: 606982; MGI: 1341724; HomoloGene: 31267; GeneCards: GGPS1; OMA:GGPS1 - orthologs
EC number	2.5.1.1
Gene location (Human)
Chr.	Chromosome 1 (human)
End	235,344,532 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	14,238,073 bp
RNA expression pattern
	Top expressed in
	sperm; ; ganglionic eminence; ; islet of Langerhans; ; skin of thigh; ; glutes; ; optic nerve; ; epithelium of colon; ; gingival epithelium; ; left testis; ; right testis;
	Top expressed in
	Rostral migratory stream; ; pineal gland; ; genital tubercle; ; tail of embryo; ; medial ganglionic eminence; ; ventricular zone; ; lateral geniculate nucleus; ; dentate gyrus of hippocampal formation granule cell; ; epithelium of lens; ; seminal vesicula;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; farnesyltranstransferase activity; protein binding; metal ion binding; dimethylallyltranstransferase activity; geranyltranstransferase activity; identical protein binding;
Cellular component	cytoplasm; cytosol;
Biological process	cholesterol biosynthetic process; farnesyl diphosphate biosynthetic process; geranyl diphosphate biosynthetic process; geranylgeranyl diphosphate biosynthetic process; isoprenoid biosynthetic process; isoprenoid metabolic process; regulation of cholesterol biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	9453
	14593
	ENSG00000152904
	ENSMUSG00000021302
	O95749
	Q9WTN0
	NM_001037277; NM_001037278; NM_004837; NM_001371477; NM_001371478
NM_010282; NM_001331119; NM_001331176; NM_001331177; NM_001331178;
	NM_001331180
NP_001032354; NP_001032355; NP_001358406; NP_001358407; NP_004828;
	NP_001032354.1
NP_001318048; NP_001318105; NP_001318106; NP_001318107; NP_001318109;
	NP_034412
	Wikidata
View/Edit Human	View/Edit Mouse

Geranylgeranyl pyrophosphate synthetase is an enzyme that in humans is encoded by the GGPS1 gene.^[5]^[6]^[7]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000152904 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021302 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ericsson, J.; Greene, J.M.; Carter, K.C.; Shell, B.K.; Duan, D.R.; Florence, C.; Edwards, P.A. (December 1998). "Human geranylgeranyl diphosphate synthase: isolation of the cDNA, chromosomal mapping and tissue expression". Journal of Lipid Research. 39 (9): 1731–1739. PMID 9741684.
^ Kainou, T.; Kawamura, K.; Tanaka, K.; Matsuda, H.; Kawamukai, M. (May 1999). "Identification of the GGPS1 genes encoding geranylgeranyl diphosphate synthases from mouse and human". Biochimica et Biophysica Acta. 1437 (3): 333–340. doi:10.1016/S1388-1981(99)00028-1. PMID 10101267.
^ "Entrez Gene: GGPS1 geranylgeranyl diphosphate synthase 1".

References

Further reading