GZMB

GZMB
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1FQ3, 1IAU
Identifiers
Aliases	GZMB, CCPI, CGL-1, CGL1, CSP-B, CSPB, CTLA1, CTSGL1, HLP, SECT, granzyme B, C11
External IDs	OMIM: 123910; MGI: 109267; HomoloGene: 108184; GeneCards: GZMB; OMA:GZMB - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	24,634,267 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	56,499,717 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; blood; ; mononuclear cell; ; monocyte; ; spleen; ; bone marrow; ; decidua; ; lymph node; ; right lung; ; appendix;
	Top expressed in
	gastrula; ; jejunum; ; duodenum; ; decidua; ; blood; ; intestinal villus; ; embryo; ; pharynx; ; uterus; ; seminal vesicula;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptidase activity; protein binding; serine-type peptidase activity; serine-type endopeptidase activity; hydrolase activity;
Cellular component	cytosol; membrane; immunological synapse; nucleus; mitochondrion; secretory granule; cytoplasm;
Biological process	cytolysis; proteolysis; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; natural killer cell mediated cytotoxicity; apoptotic process; granzyme-mediated apoptotic signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	3002
	14939
	ENSG00000100453
	ENSMUSG00000015437
	P10144
	P04187
	NM_004131; NM_001346011
	NM_013542
	NP_001332940; NP_004122
	NP_038570
	Wikidata
View/Edit Human	View/Edit Mouse

Granzyme B is a serine protease that in humans is encoded by the GZMB gene.^[5] Granzyme B is expressed by cytotoxic T lymphocytes (CTL) and natural killer (NK) cells.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000100453 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000015437 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Dahl CA, Bach FH, Chan W, Huebner K, Russo G, Croce CM, Herfurth T, Cairns JS (May 1990). "Isolation of a cDNA clone encoding a novel form of granzyme B from human NK cells and mapping to chromosome 14". Hum Genet. 84 (5): 465–70. doi:10.1007/bf00195821. PMID 2323780.

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