Glycine transaminase

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glycine transaminase
EC no.
CAS no.9032-99-9
IntEnzIntEnz view
ExPASyNiceZyme view
MetaCycmetabolic pathway
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a glycine transaminase (EC is an enzyme that catalyzes the chemical reaction

glycine + 2-oxoglutarate glyoxylate + L-glutamate

Thus, the two substrates of this enzyme are glycine and 2-oxoglutarate, whereas its two products are glyoxylate and L-glutamate.

This reactions strongly favours synthesis of glycine.[1] This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The systematic name of this enzyme class is glycine:2-oxoglutarate aminotransferase. Other names in common use include glutamic-glyoxylic transaminase, glycine aminotransferase, glyoxylate-glutamic transaminase, L-glutamate:glyoxylate aminotransferase, and glyoxylate-glutamate aminotransferase. This enzyme participates in glycine, serine and threonine metabolism. It employs one cofactor, pyridoxal phosphate.


  1. ^ Textbook of Biochemistry for Medical Students, by DM Vasudevan, Sreekumari S, Kannan Vaidyanathan, 9th edition, page 283.
  • Nakada HI (1964). "Glutamic-glycine transaminase from rat liver". J. Biol. Chem. 239: 468–471. PMID 14169146.
  • Thompson JS, Richardson KE (1966). "Isolation and characterization of a glutamate-glycine transaminase from human liver". Arch. Biochem. Biophys. 117 (3): 599–603. doi:10.1016/0003-9861(66)90101-9.