Goblet cell carcinoid

From Wikipedia, the free encyclopedia

This is an old revision of this page, as edited by Mikael Häggström (talk | contribs) at 09:52, 8 March 2017 (Translated from French). The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.

Goblet cell carcinoid

The goblet cell carcinoid, abbreviated GCC and also known as crypt cell carcinoma and neuroendocrine tumour with goblet cell differentiation, is a rare biphasic gastrointestinal tract tumour that consists of a neuroendocrine component and a conventional carcinoma, histologically arising from Paneth cells.[1]

Sign and symptoms

GCCs may present as appendicitis.

Diagnosis

Micrograph of a goblet cell carcinoid. H&E stain.

GCCs are diagnosed by pathology. They have a characteristic biphasic appearance which includes (1) goblet cell-like cells, and (2) neuroendocrine-type nuclear chromatin (stippled chromatin).

Prognosis

GCCs have an aggressive course compared to other appendiceal neuroendocrine tumours.[1]

Treatment

GCCs are treated with surgery.

See also

References

  1. ^ a b van Eeden S, Offerhaus GJ, Hart AA, et al. (December 2007). "Goblet cell carcinoid of the appendix: a specific type of carcinoma". Histopathology. 51 (6): 763–73. doi:10.1111/j.1365-2559.2007.02883.x. PMID 18042066.
Wikimedia Commons has media related to Goblet cell carcinoid.
Retrieved from "https://en.wikipedia.org/w/index.php?title=Goblet_cell_carcinoid&oldid=769237899"