Jump to content

HBcAg

From Wikipedia, the free encyclopedia

This is an old revision of this page, as edited by HyperGaruda (talk | contribs) at 10:14, 28 April 2016 (MoS-ified image markup; replaced genome image by an identical but qualitatively superior svg version). The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.

A simplified drawing of the HBV particle and surface antigen. Purple = Lipid Envelope, Red = Nucleocapsid Core (Note: This drawing is slightly misleading in that the nucleocapsid core is a single entity even though it is depicted as a light blue icosahedral line shape and a red ring of circles).
The genome organisation of HBV. The genes overlap. (ORF Core, at bottom left, encodes HBcAg.

HBcAg (core antigen) is a hepatitis B viral protein.[1][2] It is an indicator of active viral replication; this means the person infected with Hepatitis B can likely transmit the virus on to another person (i.e. the person is infectious).

Structure and Function

HBcAg is an antigen can be found on the surface of the nucleocapsid core (the inner most layer of the hepatitis b virus). While both HBcAg and HBeAg are made from the same reading frame, HBcAg is not secreted. HBcAg is considered "particulate" and it does not circulate in the blood. However, it is readily detected in hepatocytes after biopsy. The presence of both HBcAg and HBeAg proteins together act as a marker of viral replication, and antibodies to these antigens are a marker of declining replication.

Interactions

Tapasin can interact with HBcAg18-27 and enhance cytotoxic T lymphocyte response against HBV.[3]

See Also

Hepatitis B Extracellular Antigen

References

  1. ^ Kimura T, Rokuhara A, Matsumoto A, et al. (May 2003). "New enzyme immunoassay for detection of hepatitis B virus core antigen (HBcAg) and relation between levels of HBcAg and HBV DNA". J. Clin. Microbiol. 41 (5): 1901–6. doi:10.1128/JCM.41.5.1901-1906.2003. PMC 154683. PMID 12734224.
  2. ^ Cao T, Meuleman P, Desombere I, Sällberg M, Leroux-Roels G (December 2001). "In vivo inhibition of anti-hepatitis B virus core antigen (HBcAg) immunoglobulin G production by HBcAg-specific CD4(+) Th1-type T-cell clones in a hu-PBL-NOD/SCID mouse model". J. Virol. 75 (23): 11449–56. doi:10.1128/JVI.75.23.11449-11456.2001. PMC 114731. PMID 11689626.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  3. ^ Chen X (May 2014). "Tapasin modification on the intracellular epitope HBcAg18-27 enhances HBV-specific CTL immune response and inhibits hepatitis B virus replication in vivo". Lab Invest. 94 (5): 478–90. doi:10.1038/labinvest.2014.6. PMID 24614195.


Stub icon

This virus-related article is a stub. You can help Wikipedia by expanding it.

Retrieved from "https://en.wikipedia.org/w/index.php?title=HBcAg&oldid=717547105"