HIST1H1A

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HIST1H1A
Identifiers
Aliases HIST1H1A, H1.1, H1A, H1F1, HIST1, histone cluster 1, H1a
External IDs HomoloGene: 134658 GeneCards: HIST1H1A
RNA expression pattern
PBB GE HIST1H1A 208484 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005325

n/a

RefSeq (protein)

NP_005316

n/a

Location (UCSC) Chr 6: 26.02 – 26.02 Mb n/a
PubMed search [1] n/a
Wikidata
View/Edit Human

Histone H1.1 is a protein that in humans is encoded by the HIST1H1A gene.[2][3][4]

Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ Eick S, Nicolai M, Mumberg D, Doenecke D (Sep 1989). "Human H1 histones: conserved and varied sequence elements in two H1 subtype genes". Eur J Cell Biol. 49 (1): 110–5. PMID 2759094. 
  3. ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966. 
  4. ^ a b "Entrez Gene: HIST1H1A histone cluster 1, H1a". 

Further reading[edit]