HIST1H2BK

H2BC12
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2CV5
Identifiers
Aliases	H2BC12, H2B/S, H2BFAiii, H2BFT, H2BK, histone cluster 1, H2bk, histone cluster 1 H2B family member k, H2B clustered histone 12, HIST1H2BK
External IDs	OMIM: 615045; MGI: 2448399; HomoloGene: 135980; GeneCards: H2BC12; OMA:H2BC12 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	27,146,855 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	22,220,515 bp
RNA expression pattern
	Top expressed in
	bone marrow cells; ; monocyte; ; blood; ; Achilles tendon; ; placenta; ; mucosa of transverse colon; ; spleen; ; gonad; ; prostate; ; uterine tube;
	Top expressed in
	uterus; ; zygote; ; secondary oocyte; ; primary oocyte; ; white adipose tissue; ; bone marrow; ; adrenal gland; ; spermatid; ; urinary bladder; ; embryo;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; protein heterodimerization activity; molecular function;
Cellular component	nucleoplasm; nucleosome; nucleus; chromosome; extracellular space; cytosol;
Biological process	nucleosome assembly; innate immune response in mucosa; defense response to bacterium; protein ubiquitination; antimicrobial humoral immune response mediated by antimicrobial peptide;
	Sources:Amigo / QuickGO
Orthologs
	85236
	319184
	ENSG00000197903
	ENSMUSG00000062727
	O60814
	Q8CGP1
	NM_080593; NM_001312653
	NM_175665
	NP_001299582; NP_542160
	NP_783596
	Wikidata
View/Edit Human	View/Edit Mouse

Histone H2B type 1-K is a protein that in humans is encoded by the HIST1H2BK gene.^[5]^[6]

Interactions

HIST1H2BK has been shown to interact with HIRA.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000197903 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000062727 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
^ "Entrez Gene: HIST1H2BK histone cluster 1, H2bk".
^ Lorain, S; Quivy J P; Monier-Gavelle F; Scamps C; Lécluse Y; Almouzni G; Lipinski M (Sep 1998). "Core Histones and HIRIP3, a Novel Histone-Binding Protein, Directly Interact with WD Repeat Protein HIRA". Mol. Cell. Biol. 18 (9). UNITED STATES: 5546–56. ISSN 0270-7306. PMC 109139. PMID 9710638. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)