HS3ST1

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HS3ST1
Protein HS3ST1 PDB 1vkj.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases HS3ST1, 3OST, 3OST1, heparan sulfate-glucosamine 3-sulfotransferase 1
External IDs MGI: 1201606 HomoloGene: 3751 GeneCards: HS3ST1
RNA expression pattern
PBB GE HS3ST1 205466 s at fs.png

PBB GE HS3ST1 205465 x at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005114

NM_010474

RefSeq (protein)

NP_005105

NP_034604.1
NP_034604

Location (UCSC) Chr 4: 11.39 – 11.43 Mb Chr 5: 39.61 – 39.76 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Heparan sulfate glucosamine 3-O-sulfotransferase 1 is an enzyme that in humans is encoded by the HS3ST1 gene.[3][4]

Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. It possesses both heparan sulfate glucosaminyl 3-O-sulfotransferase activity, anticoagulant heparan sulfate conversion activity, and is a rate limiting enzyme for synthesis of anticoagulant heparan. This enzyme is an intraluminal Golgi resident protein.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Shworak NW, Liu J, Petros LM, Zhang L, Kobayashi M, Copeland NG, Jenkins NA, Rosenberg RD (Mar 1999). "Multiple isoforms of heparan sulfate D-glucosaminyl 3-O-sulfotransferase. Isolation, characterization, and expression of human cdnas and identification of distinct genomic loci". J Biol Chem. 274 (8): 5170–84. doi:10.1074/jbc.274.8.5170. PMID 9988767. 
  4. ^ a b "Entrez Gene: HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1". 

Further reading[edit]