HSD17B12

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HSD17B12
Identifiers
Aliases HSD17B12, KAR, SDR12C1, hydroxysteroid (17-beta) dehydrogenase 12, hydroxysteroid 17-beta dehydrogenase 12
External IDs MGI: 1926967 HomoloGene: 95094 GeneCards: HSD17B12
RNA expression pattern
PBB GE HSD17B12 217869 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_016142

NM_019657

RefSeq (protein)

NP_057226

NP_062631.1
NP_062631

Location (UCSC) Chr 11: 43.68 – 43.86 Mb Chr 2: 94.03 – 94.16 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Estradiol 17-beta-dehydrogenase 12 is an enzyme that in humans is encoded by the HSD17B12 gene.[3][4][5]

The enzyme 17-beta hydroxysteroid dehydrogenase-12 (HSD17B12) uses NADPH to reduce 3-ketoacyl-CoA to 3-hydroxyacyl-CoA during the second step of fatty acid elongation.[supplied by OMIM][5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Moon YA, Horton JD (Feb 2003). "Identification of two mammalian reductases involved in the two-carbon fatty acyl elongation cascade". J Biol Chem. 278 (9): 7335–43. doi:10.1074/jbc.M211684200. PMID 12482854. 
  4. ^ Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jornvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (Feb 2009). "The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative". Chem Biol Interact. 178 (1-3): 94–8. doi:10.1016/j.cbi.2008.10.040. PMC 2896744Freely accessible. PMID 19027726. 
  5. ^ a b "Entrez Gene: HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12". 

Further reading[edit]