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A heart transplant, or a cardiac transplant, is a surgical transplant procedure performed on patients with end-stage heart failure or severe coronary artery disease when other medical or surgical treatments have failed. As of 2016, the most common procedure is to take a functioning heart (with or without transplantation of a lung or lungs; a cadaveric donor cardiectomy) from a recently deceased organ donor (the cadaveric allograft), and implant it into the patient. The patient's own heart is either removed (the cardiectomy for the recipient) and replaced with the donor heart (orthotopic procedure) or, less commonly, the recipient's diseased heart is left in place to support the donor heart (heterotopic procedure). Approximately 3500 heart transplants are performed every year in the world, more than half of which occur in the US. Post-operation survival periods average 15 years. Heart transplantation is not considered to be a cure for heart disease, but a life-saving treatment intended to improve the quality of life for recipients.
One of the first mentions of the possibility of heart transplantation was by American medical researcher Simon Flexner, who declared in a reading of his paper on “Tendencies in Pathology” in the University of Chicago in 1907 that it would be possible in the then-future for diseased human organs substitution for healthy ones by surgery — including arteries, stomach, kidneys and heart.
Norman Shumway is widely regarded as the father of heart transplantation. Barnard performed the first transplant on Louis Washkansky on December 3, 1967, at the Groote Schuur Hospital in Cape Town, South Africa. although the world's first adult human heart transplant was performed by a South African cardiac surgeon, Christiaan Barnard, utilizing the techniques developed and perfected by Shumway and Richard Lower. Barnard performed the first transplant on Louis Washkansky on December 3, 1967, at the Groote Schuur Hospital in Cape Town, South Africa. Adrian Kantrowitz performed the world's first pediatric heart transplant on December 6, 1967, at Maimonides Hospital in Brooklyn, New York, barely three days after Christiaan Barnard's pioneering operation. Since the 19-day-old infant died little more than six hours after receiving the heart, this operation was considered a failure.Norman Shumway performed the first adult heart transplant in the United States on January 6, 1968, at the Stanford University Hospital.
On 9 June 1984 “JP” Lovette IV of Denver became the world’s first successful pediatric heart transplant. Columbia-Presbyterian Medical Center surgeons transplanted the heart of 4-year-old John Nathan Ford of Harlem into 4-year-old JP a day after the Harlem child died of injuries received in a fall from a fire escape at his home. JP was born with multiple heart defects. The transplant was done by a surgical team led by Dr. Eric A. Rose, director of cardiac transplantation at NewYork–Presbyterian Hospital. Drs. Keith Reemtsma and Fred Bowman also were members of the team for the six-hour operation. 
Worldwide, about 3,500 heart transplants are performed annually. The vast majority of these are performed in the United States (2,000–2,300 annually). Cedars-Sinai Medical Center in Los Angeles, California, currently is the largest heart transplant center in the world, having performed 132 adult transplants in 2015 alone. About 800,000 people have NYHA Class IV heart failure symptoms indicating advanced heart failure. The great disparity between the number of patients needing transplants and the number of procedures being performed spurred research into the transplantation of non-human hearts into humans after 1993. Xenografts from other species and artificial hearts are two less successful alternatives to allografts.
During heart transplant, the vagus nerve is severed, thus removing parasympathetic influence over the myocardium. However, some limited return of sympathetic nerves has been demonstrated in humans.
Some patients are less suitable for a heart transplant, especially if they suffer from other circulatory conditions related to their heart condition. The following conditions in a patient increase the chances of complications;
- Advanced kidney, lung, or liver disease
- Active cancer if it is likely to impact the survival of the patient
- Life-threatening diseases unrelated to heart failure including acute infection or systemic disease such as systemic lupus erythematosus, sarcoidosis, or amyloidosis
- Vascular disease of the neck and leg arteries.
- High pulmonary vascular resistance - over 5 or 6 Wood units.
- Insulin-dependent diabetes with severe organ dysfunction
- Recent thromboembolism such as stroke
- Severe obesity
- Age over 65 years (some variation between centers) - older patients are usually evaluated on an individual basis.
- Active substance abuse, such as alcohol, recreational drugs or tobacco smoking (which increases the chance of lung disease)
Post-operative complications include infection, sepsis, organ rejection, as well as the side-effects of the immunosuppressive medication. Since the transplanted heart originates from another organism, the recipient's immune system typically attempts to reject it. The risk of rejection never fully goes away, and the patient will be on immunosuppressive drugs for the rest of his or her life, but these may cause unwanted side effects, such as increased likelihood of infections or development of certain cancers. Recipients can acquire kidney disease from a heart transplant due to side effects of immunosuppressant medications. Many recent advances in reducing complications due to tissue rejection stem from mouse heart transplant procedures. Surgery death rate is 5-10% in 2011.
The prognosis for heart transplant patients following the orthotopic procedure has increased over the past 20 years, and as of June 5, 2009, the survival rates were:
- 1 year: 88.0% (males), 86.2% (females)
- 3 years: 79.3% (males), 77.2% (females)
- 5 years: 73.2% (males), 69.0% (females)
In a study spanning 1999 to 2007, conducted on behalf of the U.S. federal government by Dr. Eric Weiss of the Johns Hopkins University School of Medicine, it was discovered that, compared to men receiving male hearts, "men receiving female hearts had a 15% increase in the risk of adjusted cumulative mortality" over five years. No significant differences were noted with females receiving hearts from male or female donors.
- Cook JA, Shah KB, Quader MA, et al. The total artificial heart. Journal of Thoracic Disease. 2015;7(12):2172-2180. doi:10.3978/j.issn.2072-1439.2015.10.70.
- Till Lehmann (director) (2007). The Heart-Makers: The Future of Transplant Medicine (documentary film). Germany: LOOKS film and television.
- Burch M.; Aurora P. (2004). "Current status of paediatric heart, lung, and heart-lung transplantation". Archives of Disease in Childhood. 89 (4): 386–389. doi:10.1136/adc.2002.017186. PMC . PMID 15033856.
- MAY TRANSPLANT THE HUMAN HEART (.PDF), The New York Times, January 2, 1908.
- McRae, D. (2007). Every Second Counts. Berkley.
- "Memories of the Heart". Doylestown, Pennsylvania: Daily Intelligencer. November 29, 1987. p. A–18.
- Lyons, Richard D. "Heart Transplant Fails to Save 2-Week-old Baby in Brooklyn; Heart Transplant Fails to Save Baby Infants' Surgery Harder Working Side by Side Gives Colleague Credit", The New York Times, December 7, 1967. Accessed November 19, 2008.
- "TALK ABOUT A GUY WITH A LOT OF HEART 1st kid to get new ticker wants to be doc" NY Daily News, 13 April 2003
- "SRTR -- Scientific Registry of Transplant Recipients". www.srtr.org. Retrieved 2016-10-24.
- Reiner Körfer (interviewee) (2007). The Heart-Makers: The Future of Transplant Medicine (documentary film). Germany: LOOKS film and television.
- Arrowood, James A.; Minisi, Anthony J.; Goudreau, Evelyne; Davis, Annette B.; King, Anne L. (1997-11-18). "Absence of Parasympathetic Control of Heart Rate After Human Orthotopic Cardiac Transplantation". Circulation. 96 (10): 3492–3498. doi:10.1161/01.CIR.96.10.3492. ISSN 0009-7322. PMID 9396446.
- Mehra MR, Canter CE, Hannan MM, Semigran MJ, Uber PA, et al. The 2016 International Society for Heart Lung Transplantation listing criteria for heart transplantation: A 10-year update. J Heart Lung Transplant. 2016 Jan. 35 (1):1-23.
- Bishay R (2011). "The 'Mighty Mouse' Model in Experimental Cardiac Transplantation". Hypothesis. 9 (1): e5. doi:10.5779/hypothesis.v9i1.205.
- Jung SH, Kim JJ, Choo SJ, Yun TJ, Chung CH, Lee JW (2011). "Long-term mortality in adult orthotopic heart transplant recipients". J. Korean Med. Sci. 26: 599–603. doi:10.3346/jkms.2011.26.5.599. PMC . PMID 21532848.
- Heart Disease and Stroke Statistics--2012 Update The American Heart Association. Retrieved 27 November 2012.
- Weiss, E. S.; Allen, J. G.; Patel, N. D.; Russell, S. D.; Baumgartner, W. A.; Shah, A. S.; Conte, J. V. (2009). "The Impact of Donor-Recipient Sex Matching on Survival After Orthotopic Heart Transplantation: Analysis of 18 000 Transplants in the Modern Era". Circulation: Heart Failure. 2 (5): 401–408. doi:10.1161/CIRCHEARTFAILURE.108.844183.
-  - Heart Transplant in India
-  - The real first heart transplant.
- Official Heart Transplant Museum - Heart Of Cape Town
- Photograph of first U.S. heart transplant
- Western Cape government; South Africa (21 February 2005). "Chris Barnard Performs World's First Heart Transplant". Cape Gateway. Retrieved 2007-01-10.
- Department of Cardiothoracic Surgery. "Patient's Guide to Heart Transplant Surgery". University of Southern California. Retrieved 2007-01-10.
- Nancy Reid (22 September 2005). "Heart transplant: How is it performed?". Healthwise. Retrieved 2007-01-10.
- The Adrian Kantrowitz Papers Profiles in Science from the National Library of Medicine for Adrian Kantrowitz, the first to perform a pediatric heart transplant
- Orthotopic heart transplantation: the bicaval technique