Hexaprenyl diphosphate synthase (geranylgeranyl-diphosphate specific)
| Hexaprenyl diphosphate synthase (geranylgeranyl-diphosphate specific) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.5.1.82 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Hexaprenyl diphosphate synthase (geranylgeranyl-diphosphate specific) (EC 2.5.1.82, HexPS, (all-E) hexaprenyl diphosphate synthase, (all-trans) hexaprenyl diphosphate synthase, hexaprenyl pyrophosphate synthase, HexPPs, hexaprenyl diphosphate synthase) is an enzyme with systematic name geranylgeranyl-diphosphate:isopentenyl-diphosphate transferase (adding 2 isopentenyl units).[1][2][3] This enzyme catalyses the following chemical reaction
- geranylgeranyl diphosphate + 2 isopentenyl diphosphate 2 diphosphate + all-trans-hexaprenyl diphosphate
The enzyme prefers geranylgeranyl diphosphate to farnesyl diphosphate as an allylic substrate.
References
- ^ Hemmi, H.; Ikejiri, S.; Yamashita, S.; Nishino, T. (2002). "Novel medium-chain prenyl diphosphate synthase from the thermoacidophilic archaeon Sulfolobus solfataricus". J. Bacteriol. 184 (3): 615–620. doi:10.1128/JB.184.3.615-620.2002. PMC 139513. PMID 11790729.
- ^ Hemmi, H.; Noike, M.; Nakayama, T.; Nishino, T. (2002). "Change of product specificity of hexaprenyl diphosphate synthase from Sulfolobus solfataricus by introducing mimetic mutations". Biochem. Biophys. Res. Commun. 297 (5): 1096–1101. doi:10.1016/S0006-291X(02)02348-3. PMID 12372398.
- ^ Sun, H.Y.; Ko, T.P.; Kuo, C.J.; Guo, R.T.; Chou, C.C.; Liang, P.H.; Wang, A.H. (2005). "Homodimeric hexaprenyl pyrophosphate synthase from the thermoacidophilic crenarchaeon Sulfolobus solfataricus displays asymmetric subunit structures". J. Bacteriol. 187 (23): 8137–8148. doi:10.1128/JB.187.23.8137-8148.2005. PMC 1291270. PMID 16291686.
External links
- Hexaprenyl+diphosphate+synthase+(geranylgeranyl-diphosphate+specific) at the U.S. National Library of Medicine Medical Subject Headings (MeSH)