IFT81

From Wikipedia, the free encyclopedia
Jump to: navigation, search
IFT81
Identifiers
Aliases IFT81, CDV-1, CDV-1R, CDV1, CDV1R, DV1, intraflagellar transport 81
External IDs MGI: 1098597 HomoloGene: 7664 GeneCards: IFT81
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_009879

RefSeq (protein)

NP_034009.2
NP_034009

Location (UCSC) Chr 12: 110.12 – 110.22 Mb Chr 5: 122.55 – 122.61 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Intraflagellar transport protein 81 homolog is a protein that in humans is encoded by the IFT81 gene.[3][4] Together with IFT74/72 it forms a core complex to build IFT particles[5] which are required for cilium formation. Additionally, it interacts with basal body components as CEP170[6] which regulates the disassembly of the cilium.

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ "Entrez Gene: intraflagellar transport 81 homolog (Chlamydomonas)". 
  4. ^ Higashi M, Kobayashi K, Iijima M, Wakana S, Horiuchi M, Yasuda T, Yoshida G, Kanmura Y, Saheki T (December 2000). "Genomic organization and mapping of mouse CDV (carnitine deficiency-associated gene expressed in ventricle)-1 and its related CDV-1R gene". Mamm. Genome. 11 (12): 1053–7. doi:10.1007/s003350010207. PMID 11130971. 
  5. ^ Lucker BF, Behal RH, Qin H, Siron LC, Taggart WD, Rosenbaum JL, Cole DG (July 2005). "Characterization of the intraflagellar transport complex B core: direct interaction of the IFT81 and IFT74/72 subunits". J. Biol. Chem. 280 (30): 27688–96. doi:10.1074/jbc.M505062200. PMID 15955805. 
  6. ^ Lamla, Stefan (2009). Functional characterisation of the centrosomal protein Cep170 (Thesis). LMU München: Faculty of Biology. 

Further reading[edit]