IFT81

IFT81
Identifiers
Aliases	IFT81, CDV-1, CDV-1R, CDV1, CDV1R, DV1, intraflagellar transport 81, SRTD19
External IDs	OMIM: 605489; MGI: 1098597; HomoloGene: 7664; GeneCards: IFT81; OMA:IFT81 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	110,218,793 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	122,752,581 bp
RNA expression pattern
	Top expressed in
	bronchial epithelial cell; ; ventricular zone; ; right uterine tube; ; ganglionic eminence; ; Achilles tendon; ; olfactory zone of nasal mucosa; ; testicle; ; Epithelium of choroid plexus; ; left testis; ; right testis;
	Top expressed in
	spermatid; ; saccule; ; spermatocyte; ; neural layer of retina; ; interventricular septum; ; genital tubercle; ; otic vesicle; ; vestibular sensory epithelium; ; right ventricle; ; olfactory epithelium;
	More reference expression data
	n/a
Gene ontology
Molecular function	tubulin binding; protein binding;
Cellular component	intraciliary transport particle B; ciliary basal body; centrosome; sperm principal piece; cell projection; ciliary tip; motile cilium; sperm midpiece; cilium;
Biological process	cell projection organization; spermatogenesis; intraciliary transport; intraciliary transport involved in cilium assembly; cilium assembly; regulation of smoothened signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	28981
	12589
	ENSG00000122970
	ENSMUSG00000029469
	Q8WYA0
	O35594
NM_001143779; NM_014055; NM_031473; NM_001347946; NM_001347947;
	NM_001347948
	NM_009879; NM_001358917; NM_001358918; NM_001358919
NP_001137251; NP_054774; NP_113661; NP_001334875; NP_001334876;
	NP_001334877; NP_001137251.1; NP_054774.2
	NP_034009; NP_001345846; NP_001345847; NP_001345848
	Wikidata
View/Edit Human	View/Edit Mouse

Intraflagellar transport protein 81 homolog is a protein that in humans is encoded by the IFT81 gene.^[5]^[6] Together with IFT74/72 it forms a core complex to build IFT particles^[7] which are required for cilium formation. Additionally, it interacts with basal body components as CEP170^[8] which regulates the disassembly of the cilium.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000122970 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029469 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: intraflagellar transport 81 homolog (Chlamydomonas)".
^ Higashi M, Kobayashi K, Iijima M, Wakana S, Horiuchi M, Yasuda T, Yoshida G, Kanmura Y, Saheki T (December 2000). "Genomic organization and mapping of mouse CDV (carnitine deficiency-associated gene expressed in ventricle)-1 and its related CDV-1R gene". Mamm. Genome. 11 (12): 1053–7. doi:10.1007/s003350010207. PMID 11130971.
^ Lucker BF, Behal RH, Qin H, Siron LC, Taggart WD, Rosenbaum JL, Cole DG (July 2005). "Characterization of the intraflagellar transport complex B core: direct interaction of the IFT81 and IFT74/72 subunits". J. Biol. Chem. 280 (30): 27688–96. doi:10.1074/jbc.M505062200. PMID 15955805.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ Lamla, Stefan (2009). Functional characterisation of the centrosomal protein Cep170 (Thesis). LMU München: Faculty of Biology.

Melzer D, Perry JR, Hernandez D, et al. (2008). Cheung VG (ed.). "A genome-wide association study identifies protein quantitative trait loci (pQTLs)". PLoS Genet. 4 (5): e1000072. doi:10.1371/journal.pgen.1000072. PMC 2362067. PMID 18464913.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Peng J, Yu L, Horiuchi M, et al. (2002). "Identification of human CDV-1R and mouse Cdv-1R, two novel proteins with putative signal peptides, especially highly expressed in testis and increased with the male sex maturation". Mol. Biol. Rep. 29 (4): 353–62. doi:10.1023/A:1021232518628. PMID 12549821.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000122970 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029469 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: intraflagellar transport 81 homolog (Chlamydomonas)".

[pmid11130971-6] Higashi M, Kobayashi K, Iijima M, Wakana S, Horiuchi M, Yasuda T, Yoshida G, Kanmura Y, Saheki T (December 2000). "Genomic organization and mapping of mouse CDV (carnitine deficiency-associated gene expressed in ventricle)-1 and its related CDV-1R gene". Mamm. Genome. 11 (12): 1053–7. doi:10.1007/s003350010207. PMID 11130971.

[pmid15955805-7] Lucker BF, Behal RH, Qin H, Siron LC, Taggart WD, Rosenbaum JL, Cole DG (July 2005). "Characterization of the intraflagellar transport complex B core: direct interaction of the IFT81 and IFT74/72 subunits". J. Biol. Chem. 280 (30): 27688–96. doi:10.1074/jbc.M505062200. PMID 15955805.{{cite journal}}: CS1 maint: unflagged free DOI (link)

[Lamla_thesis-8] Lamla, Stefan (2009). Functional characterisation of the centrosomal protein Cep170 (Thesis). LMU München: Faculty of Biology.

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References

Further reading