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INPP5A

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INPP5A
Identifiers
AliasesINPP5A, 5PTASE, inositol polyphosphate-5-phosphatase A
External IDsOMIM: 600106; MGI: 2686961; HomoloGene: 4045; GeneCards: INPP5A; OMA:INPP5A - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005539
NM_001321042

NM_001127363
NM_183144
NM_001355162

RefSeq (protein)

NP_001307971
NP_005530

NP_001120835
NP_001342091
NP_898967

Location (UCSC)Chr 10: 132.54 – 132.78 MbChr 7: 138.97 – 139.16 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Type I inositol-1,4,5-trisphosphate 5-phosphatase is an enzyme that in humans is encoded by the INPP5A gene.[5][6]

The protein encoded by this gene is a membrane-associated type I inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000068383Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025477Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ De Smedt F, Verjans B, Mailleux P, Erneux C (Jul 1994). "Cloning and expression of human brain type I inositol 1,4,5-trisphosphate 5-phosphatase. High levels of mRNA in cerebellar Purkinje cells". FEBS Lett. 347 (1): 69–72. doi:10.1016/0014-5793(94)00509-5. PMID 8013665. S2CID 4936881.
  6. ^ a b "Entrez Gene: INPP5A inositol polyphosphate-5-phosphatase, 40kDa".

Further reading

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