INPP5A

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INPP5A
Identifiers
Aliases INPP5A, 5PTASE, inositol polyphosphate-5-phosphatase A
External IDs MGI: 2686961 HomoloGene: 4045 GeneCards: INPP5A
RNA expression pattern
PBB GE INPP5A 203006 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005539
NM_001321042

NM_001127363
NM_183144

RefSeq (protein)

NP_001307971
NP_005530

n/a

Location (UCSC) Chr 10: 132.54 – 132.78 Mb Chr 7: 139.39 – 139.58 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Type I inositol-1,4,5-trisphosphate 5-phosphatase is an enzyme that in humans is encoded by the INPP5A gene.[3][4]

The protein encoded by this gene is a membrane-associated type I inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ De Smedt F, Verjans B, Mailleux P, Erneux C (Jul 1994). "Cloning and expression of human brain type I inositol 1,4,5-trisphosphate 5-phosphatase. High levels of mRNA in cerebellar Purkinje cells". FEBS Lett. 347 (1): 69–72. PMID 8013665. doi:10.1016/0014-5793(94)00509-5. 
  4. ^ a b "Entrez Gene: INPP5A inositol polyphosphate-5-phosphatase, 40kDa". 

Further reading[edit]