She studied acting at the Teatès School in Palermo, under director Michele Perriera. During her studies, she wrote, directed and starred in several adpations of his plays. In 1998 she won the first prize at INDA (National Institute for Ancient Drama), with a short essay on the figure of Hecuba. She graduated in 2000 with a diploma in acting.
|2008||Detesto l'elettronica stop||Film||Margherita||Director Cosimo Messeri|
|Tutta la vita davanti||Film||Martha||Director Paolo Virzi. Nominated for best leading actress at the 2008 Silver Ribbon|
|Viola di mare||Film||Sara||Director Donatella Majorca, based on the book Dave King by Giacomo Pilati|
|Mamùr||Opera||Part written for Isabella Ragonese|
|2009||Due vite per caso||Film||Sonia||Director Alessandro Aronadio|
|Oggi sposi||Film||Chiara Malagò||Director Luca Lucini|
|Ten Winters||Film||Camilla||Director Valerio Mieli|
|2010||La nostra vita||Film||Elena||Director Daniele Luchetti|
|2011||Inspector Montalbano||Television||Lt. Laura Belladonna||Episode The Age of Doubt|
|Il primo incarico||Film||Nena|
|Il giorno in più||Film||Michela|
|2012||Orlando||Play||Orlando||Director Emanuela Giordano. Based on the novel Orlando: A Biography by Virginia Woolf|
|2013||Taking Care of Baby||Play||Staged at the Teatro Eliseo, Rome|
|2014||Il giovane favoloso|
- Nastro d'Argento for Best supporting Actress 2010: La nostra vita & Due vite per caso (ex-aequo)
- Shooting Stars Award 2012: Isabella will receive this award at the 62nd Berlin International Film Festival in February 2012, annual acting award for up-and-coming actors by European Film Promotion.
- Blaney, Martin (2011-12-08). "European Film Promotion unveils 2012 Shooting Stars longlist | News | Screen". Screendaily.com. Retrieved 2011-12-14.
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