Journal of Clinical Investigation

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Journal of Clinical Investigation  
Journal of Clinical Investigation sample cover image (August 2015).jpg
J. Clin. Investig.
Discipline Biomedicine
Language English
Edited by Gordon F. Tomaselli
Publication details
Publication history
Frequency Monthly; articles published weekly online
ISSN 0021-9738 (print)
1558-8238 (web)
LCCN 27010044
OCLC no. 01445593

The Journal of Clinical Investigation (JCI) is a peer-reviewed biomedical research journal published by the American Society for Clinical Investigation (ASCI).

Evaluation and peer review of research[edit]

The JCI receives submissions from authors worldwide. Unlike at most commercial journals, an Editorial Board made up of scientists actively engaged in scientific discovery rigorously evaluates each submitted article for scientific merit to determine its suitability for the JCI. Submitted manuscripts are sent out for external peer review if the board member with specific expertise in the subject area handling the manuscript believes it represents a substantial conceptual advance and is appropriate for the broad readership of the JCI. The JCI strives for timely and thoughtful decisions on manuscripts that incorporate the recommendations from peer review and the discussion at a weekly Editorial Board meeting.


Research articles focus on the mechanisms of disease, with an emphasis on basic research, early-stage clinical studies in humans, and new research tools and techniques. The JCI also publishes scientific reviews in edited series or as stand-alone articles, commentaries on research, editorials, and feature items. Multimedia content on the journal's website provides in-depth perspectives on article content and other information of interest to JCI readers. A companion to the journal, JCI This Month, launched in January 2013, summarizes and highlights the content of each month's issue.

Current Editorial Board[edit]

The Editorial Board comprises scientists associated with an academic medical center, which changes every five years, allowing for new editorial perspectives and areas of expertise. The journal is headed by Editor in Chief Dr. Gordon F. Tomaselli and an Editorial Board of peer scientists at Johns Hopkins University.

Influential research[edit]

The top-cited JCI articles as of October 2017, according to Scopus

Title Year published No. of citations
Havel, RJ; Eder, HA; Bragdon, JH. "The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum". Journal of Clinical Investigation. 34: 1345–1353. doi:10.1172/JCI103182. PMC 438705Freely accessible. PMID 13252080.  1955 6051
Jaffe, EA; Nachman, RL; Becker, CG; et al. "Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria". Journal of Clinical Investigation. 52: 2745–2756. doi:10.1172/JCI107470. PMC 302542Freely accessible. PMID 4355998.  1973 5476
Weisberg, SP; McCann, D; Desai, M; et al. "Obesity is associated with macrophage accumulation in adipose tissue". Journal of Clinical Investigation. 112: 1796–1808. doi:10.1172/JCI19246. PMC 296995Freely accessible. PMID 14679176.  2003 4971
Xu, H; Barnes, GT; Yang, Q; et al. "Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance". Journal of Clinical Investigation. 112: 1821–1830. doi:10.1172/JCI19451. PMC 296998Freely accessible. PMID 14679177.  2003 3628
Rigat, B; Hubert, C; Alhenc-Gelas, F; et al. "An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels". Journal of Clinical Investigation. 86: 1343–1346. doi:10.1172/JCI114844. PMC 296868Freely accessible. PMID 1976655.  1990 3040
Zhou, G; Myers, R; Li, Y; et al. "Role of AMP-activated protein kinase in mechanism of metformin action". Journal of Clinical Investigation. 108: 1167–1174. doi:10.1172/JCI13505. PMC 209533Freely accessible. PMID 11602624.  2001 2994
Furukawa, S; Fujita, T; Shimabukuro, M; et al. "Increased oxidative stress in obesity and its impact on metabolic syndrome". Journal of Clinical Investigation. 114: 1752–1761. doi:10.1172/JCI200421625. PMC 535065Freely accessible. PMID 15599400.  2004 2399
Hotamisligil, GS; Arner, P; Caro, JF; et al. "Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance". Journal of Clinical Investigation. 95: 2409–2415. doi:10.1172/JCI117936. PMC 295872Freely accessible. PMID 7738205.  1995 2385
Witztum, JL; Steinberg, D. "Role of oxidized low density lipoprotein in atherogenesis". Journal of Clinical Investigation. 88: 1785–1792. doi:10.1172/JCI115499. PMC 295745Freely accessible. PMID 1752940.  1991 2227
Maynard, SE; Min, JY; Merchan, J; et al. "Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction hypertension, and proteinuria in preeclampsia". Journal of Clinical Investigation. 111: 649–658. doi:10.1172/JCI17189. PMC 151901Freely accessible. PMID 12618519.  2003 2159
Fadok, VA; Bratton, DL; Konowal, A; et al. "Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF". Journal of Clinical Investigation. 101: 890–898. doi:10.1172/JCI1112. PMC 508637Freely accessible. PMID 9466984.  1998 2000

Business model[edit]

The JCI is a nonprofit publication of the ASCI, with a publishing office in Ann Arbor, Michigan. All JCI research articles are freely available online upon publication. Revenue derives from submission fees, which support maintenance of an Editorial Board; article processing charges to authors for published articles; and subscription fees, which apply in the case of most non-research articles.

Open access[edit]

The JCI has made its research articles freely available to all readers since the journal established its online version in 1996. Although authors of research articles must transfer copyright to the journal prior to publication, the JCI allows liberal noncommercial reuse of article information. Authors may deposit their published articles in academic and other repositories. Authors may use and distribute their articles and the information contained therein following the fair-use doctrine of U.S. copyright law. For those research articles authored by employees of the U.S. government, no copyright applies, and these articles are considered to be in the public domain.

In 1996, when the journal established its online version, Ajit Varki (then Editor) wrote, "The vexing issue of the day is how to appropriately charge users for this electronic access. The nonprofit nature of the JCI allows consideration of a truly novel solution — not to charge anyone at all! It remains to be seen whether this will be fiscally feasible."[1] A 2003 JCI editorial provides an update on the fiscal landscape: "The JCI has been able to turn technology to its advantage: in 1999, it became a self-published journal, and for several years it has used web-based technology to conduct peer review and other aspects of its business, resulting in greater efficiency at lower cost. Most importantly, it has been shifting from a reliance on print-subscription revenue to author charges."[2]

The JCI was an early participant in PubMed Central (PMC), the U.S. government repository of open-access articles that began service in 2000. The JCI began participation in PMC in 2003 with the deposit of the JCI's entire publication history in scanned form where no native digital material existed and in full digital form otherwise (1996 and after). All JCI content was available in PMC without any delay until 2009, when JCI instituted a calendar-year embargo at PMC on most non-research articles. In 2014, the JCI instituted a 3-month embargo at PMC on all research articles; however, all research articles remain freely available at the time of publication at the JCI's own website.


The JCI was established by the ASCI in 1924 to serve as the major U.S. venue for research on disease and clinical medicine. A publication of the American Society for Clinical Investigation, the journal initially received financial backing from the Rockefeller Institute for Medical Research (now known as Rockefeller University). The journal then turned to a model based on individual and university clinic subscriptions. At a time of financial struggles during the Great Depression, the Chemical Foundation ran the JCI (1931–1940). Page charges were instituted in 1965 to offset publication costs. Rockefeller University Press published the journal from 1967 until 1999. Since that time, the ASCI has self-published the JCI. In 1996, when the JCI launched its online version, it became one of the first major scientific journals to make its content available barrier-free online.[3]

Several articles focus on the history of the journal:

Editors of the Journal of Clinical Investigation

Name Tenure Affiliation
G. Canby Robinson 1924–1927 Vanderbilt University
J. Harold Austin 1928–1934 University of Pennsylvania
Randolph West 1935–1940 Presbyterian Hospital (New York)
James L. Gamble 1941–1946 Harvard University
Eugene B. Ferris 1947–1951 Cincinnati General Hospital
Stanley E. Bradley 1952–1956 Columbia University
Philip K. Bondy 1957–1961 Yale University
Arnold S. Relman 1962–1966 Harvard University
Paul Marks (scientist) 1967–1970 Columbia University
DeWitt S. Goodman 1971–1972 Columbia University
Jean D. Wilson 1972–1977 University of Texas Southwestern Medical Center
Philip W. Majerus 1977–1981 Washington University
Stuart Kornfeld 1981–1982 Washington University
Thomas P. Stossel 1982–1985 Harvard University
Joseph Avruch 1986–1987 Harvard University
Bruce F. Scharschmidt 1987–1992 University of California–San Francisco
Ajit P. Varki 1992–1996 University of California–San Diego
Paul A. Insel 1996–1997 University of California–San Diego
Martin F. Kagnoff 1996–1997 University of California–San Diego
Stephen J. Weiss 1997–2002 University of Michigan
Andrew Marks 2002–2007 Columbia University
Laurence A. Turka 2007–2012 University of Pennsylvania
Howard A. Rockman 2012–2017 Duke University
Gordon F. Tomaselli 2017–2022 Johns Hopkins University


  1. ^ Varki, A (1996). "The times they are still a'changing: keeping up with the times". J Clin Invest. 97 (1): 1–1. doi:10.1172/JCI118375. PMC 507053Freely accessible. PMID 8550819. 
  2. ^ Hawley, JB (2003). "The JCI's commitment to excellence — and free access". J Clin Invest. 112 (7): 968–969. doi:10.1172/JCI20030. 
  3. ^ Howell, JD (2009). "A history of the American Society for Clinical Investigation". J Clin Invest. 119 (4): 694. doi:10.1172/JCI39091. 

External links[edit]