Richard got his first NFL start September 7, 2008 against the Chicago Bears. He replaced Jeff Saturday at center who was injured. On December 28, 2008 against the Tennessee Titans he confidently secured a loose football in the end zone against the visiting Titans, capping a 23-0 shutout. Richard was named to PFW's All-Rookie team for his role on the interior offensive line for the Colts.
On September 12, 2011, he was waived by the Colts. Jameson Richard was re-signed by the Indianapolis Colts.