Jonathan Alan Hodgkin
1949 (age 70–71)
|Alma mater||University of Oxford (BA)|
University of Cambridge (PhD)
|Awards||Edward Novitski Prize (2017)|
|Institutions||Laboratory of Molecular Biology|
|Thesis||Genetic and Anatomical Aspects of the Caenorhabditis elegans Male (1974)|
|Notable students||Magdalena Skipper|
Hodgkin was educated at the University of Oxford where he graduated in 1971. He was awarded a PhD from the University of Cambridge in 1974 for research on the genetics of the worm Caenorhabditis elegans.
Career and research
Hodgkin was a scientist at the Medical Research Council (MRC) Laboratory of Molecular Biology in Cambridge. Hodgkin was one of the earliest researchers to explore the genetics of development in the nematode worm Caenorhabditis elegans. He first unraveled the genetic and maturational events in worm sex determination before extending his interest to other developmental pathways, behaviour and immunity.
Most Caenorhabditis elegans worms are self-fertilizing hermaphrodites, with two X chromosomes, but X0 males can also arise spontaneously, permitting genetic crosses. Hodgkin used genetic mutations in this tiny, fast-breeding species to define the regulatory cascade of genes that controls the development of male or hermaphrodite characteristics — providing a model for approaching development in other species.
Since 2000, Hodgkin has focused on the nematode's response to attack by bacteria, exploring highly conserved pathways of innate immunity that are also relevant to development. Through microarray analysis, he has identified antibacterial factors produced by the worm that could be candidates for new antibiotics. He has also discovered novel pathogenic bacteria that attack nematodes, which may have potential as biological pest control agents against parasitic nematodes.
Awards and honours
Hodgkin was elected a Fellow of the Royal Society (FRS) in 1990. In 2011, he received The Genetics Society Medal. Hodgkin was a member of the Faculty of 1000. He was awarded the Edward Novitski Prize by the Genetics Society of America in 2017.
- Anon (2017). "Hodgkin, Prof. Jonathan Alan". Who's Who. ukwhoswho.com (online Oxford University Press ed.). A & C Black, an imprint of Bloomsbury Publishing plc. doi:10.1093/ww/9780199540884.013.U20378. (subscription or UK public library membership required) (subscription required)
- Hodgkin, J (2017), "Frontiers of Knowledge: An Interview with 2017 Edward Novitski Prize Recipient Jonathan Hodgkin", Genetics, 207 (4): 1219–1220, doi:10.1534/genetics.117.300400 (inactive 2020-10-05), ISSN 0016-6731, PMC 5714439, PMID 29203697CS1 maint: DOI inactive as of October 2020 (link)
- Skipper, M.; Milne, C. A.; Hodgkin, J. (1999). "Genetic and molecular analysis of fox-1, a numerator element involved in Caenorhabditis elegans primary sex determination". Genetics. 151 (2): 617–631. PMC 1460491. PMID 9927456.
- Hodgkin, JA; Brenner, S (1977). "Mutations causing transformation of sexual phenotype in the nematode Caenorhabditis elegans". Genetics. 86 (2 Pt. 1): 275–87. ISSN 0016-6731. PMC 1213677. PMID 560330.
- Jonathan Hodgkin publications indexed by the Scopus bibliographic database. (subscription required)
- "Professor Jonathan Hodgkin". keble.ox.ac.uk. Keble College, Oxford. Retrieved February 14, 2012.
- Hodgkin, Jonathan Alan (1974). Genetic and Anatomical Aspects of the Caenorhabditis elegans Male. jisc.ac.uk (PhD thesis). University of Cambridge. OCLC 500473570. EThOS uk.bl.ethos.459309.
- Hodgkin, Jonathan (2004). "Jonathan Hodgkin". Current Biology. 14 (7): R259–60. doi:10.1016/j.cub.2004.03.015. PMID 15062112. S2CID 8464632.
- Anon (1990). "Professor Jonathan Hodgkin FRS". royalsociety.org. London: Royal Society. Archived from the original on 2015-11-17. One or more of the preceding sentences incorporates text from the royalsociety.org website where:
“All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License.” --Royal Society Terms, conditions and policies at the Wayback Machine (archived 2016-11-11)
- "Jonathan Hodgkin: Former Member in Developmental Molecular Mechanisms". f1000.com. F1000. Retrieved 2012-02-14.
- "Jonathan Hodgkin awarded the 2017 Novitski Prize". genestogenomes.org. 21 March 2017. Retrieved 16 April 2019.