Jonathan Hodgkin

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Jonathan Hodgkin

Jonathan Alan Hodgkin

1949 (age 72–73)[1]
Alma materUniversity of Oxford (BA)
University of Cambridge (PhD)
AwardsEdward Novitski Prize (2017)[2]
Scientific career
InstitutionsLaboratory of Molecular Biology[3]
ThesisGenetic and Anatomical Aspects of the Caenorhabditis elegans Male (1974)
Notable studentsMagdalena Skipper[3]
InfluencesSydney Brenner[4]

Jonathan Alan Hodgkin (born 1949)[1] FRS is a British biochemist, Professor of Genetics at the University of Oxford,[5] and an emeritus fellow of Keble College, Oxford.[6]


Hodgkin was educated at the University of Oxford where he graduated in 1971.[citation needed] He was awarded a PhD from the University of Cambridge in 1974 for research on the genetics of the worm Caenorhabditis elegans.[7]

Career and research[edit]

Hodgkin was a scientist at the Medical Research Council (MRC) Laboratory of Molecular Biology in Cambridge.[8][1] Hodgkin was one of the earliest researchers to explore the genetics of development in the nematode worm Caenorhabditis elegans.[9] He first unraveled the genetic and maturational events in worm sex determination before extending his interest to other developmental pathways, behaviour and immunity.[9]

Most Caenorhabditis elegans worms are self-fertilizing hermaphrodites, with two X chromosomes, but X0 males can also arise spontaneously, permitting genetic crosses.[9] Hodgkin used genetic mutations in this tiny, fast-breeding species to define the regulatory cascade of genes that controls the development of male or hermaphrodite characteristics — providing a model for approaching development in other species.[9]

Since 2000, Hodgkin has focused on the nematode's response to attack by bacteria, exploring highly conserved pathways of innate immunity that are also relevant to development.[9] Through microarray analysis, he has identified antibacterial factors produced by the worm that could be candidates for new antibiotics.[9] He has also discovered novel pathogenic bacteria that attack nematodes, which may have potential as biological pest control agents against parasitic nematodes.[9]

Awards and honours[edit]

Hodgkin was elected a Fellow of the Royal Society (FRS) in 1990.[9] In 2011, he received The Genetics Society Medal.[9] Hodgkin was a member of the Faculty of 1000.[10] He was awarded the Edward Novitski Prize by the Genetics Society of America in 2017.[2][11]

Personal life[edit]

Hodgkin is the son of Nobel laureate Alan Lloyd Hodgkin and the editor Marni Hodgkin.[1]


  1. ^ a b c d Anon (2017). "Hodgkin, Prof. Jonathan Alan". Who's Who. (online Oxford University Press ed.). A & C Black, an imprint of Bloomsbury Publishing plc. doi:10.1093/ww/9780199540884.013.U20378. (Subscription or UK public library membership required.) (subscription required)
  2. ^ a b Hodgkin, J (2017), "Frontiers of Knowledge: An Interview with 2017 Edward Novitski Prize Recipient Jonathan Hodgkin", Genetics, 207 (4): 1219–1220, doi:10.1534/genetics.117.300400 (inactive 31 October 2021), ISSN 0016-6731, PMC 5714439, PMID 29203697CS1 maint: DOI inactive as of October 2021 (link)
  3. ^ a b Skipper, M.; Milne, C. A.; Hodgkin, J. (1999). "Genetic and molecular analysis of fox-1, a numerator element involved in Caenorhabditis elegans primary sex determination". Genetics. 151 (2): 617–631. doi:10.1093/genetics/151.2.617. PMC 1460491. PMID 9927456. open access
  4. ^ Hodgkin, JA; Brenner, S (1977). "Mutations causing transformation of sexual phenotype in the nematode Caenorhabditis elegans". Genetics. 86 (2 Pt. 1): 275–87. doi:10.1093/genetics/86.2.275. ISSN 0016-6731. PMC 1213677. PMID 560330.
  5. ^ Jonathan Hodgkin publications indexed by the Scopus bibliographic database. (subscription required)
  6. ^ "Professor Jonathan Hodgkin". Keble College, Oxford. Retrieved February 14, 2012.
  7. ^ Hodgkin, Jonathan Alan (1974). Genetic and Anatomical Aspects of the Caenorhabditis elegans Male. (PhD thesis). University of Cambridge. OCLC 500473570. EThOS
  8. ^ Hodgkin, Jonathan (2004). "Jonathan Hodgkin". Current Biology. 14 (7): R259–60. doi:10.1016/j.cub.2004.03.015. PMID 15062112. S2CID 8464632.
  9. ^ a b c d e f g h i Anon (1990). "Professor Jonathan Hodgkin FRS". London: Royal Society. Archived from the original on 2015-11-17. One or more of the preceding sentences incorporates text from the website where:

    “All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License.” --Royal Society Terms, conditions and policies at the Wayback Machine (archived 2016-11-11)

  10. ^ "Jonathan Hodgkin: Former Member in Developmental Molecular Mechanisms". F1000. Retrieved 2012-02-14.
  11. ^ "Jonathan Hodgkin awarded the 2017 Novitski Prize". 21 March 2017. Retrieved 16 April 2019.

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