Juxtaglomerular cell tumor
Juxtaglomerular cell tumor (JCT, JGCT, also reninoma) is a rare kidney cancer that typically secretes renin. It involves the juxtaglomerular cells. It often causes hypertension, in adults and children, although among causes of hypertension it is rare. Its malignant potential is uncertain.[1]
History
Juxtaglomerular cell tumor was first described in 1967. Since then, under 100 case reports have been published.[1] Karyotyping of a small number of these tumors revealed a common loss of chromosomes 9 and 11.[1]
Pathology
By hypersecretion of renin, JCT causes hypertension and hypokalemia. Both of these conditions may be corrected by surgical removal of the tumor.[2]
Diagnosis
Hypertension combined with evidence of a kidney tumor via imaging or gross examination suggest a JCT. Presence of renin granules in pathology specimens differentiates this tumor from renal hemangiopericytoma and other renal tumors.[3]
Prognosis
JCT often is described as benign, however one case of metastasis has been reported, so its malignant potential is uncertain.[1] In most cases the tumor is encapsulated.[4]
References
- ^ a b c d Capovilla M, Couturier J, Molinié V, Amsellem-Ouazana D, Priollet P, Baumert H, Bruneval P, Vieillefond A (2008). "Loss of chromosomes 9 and 11 may be recurrent chromosome imbalances in juxtaglomerular cell tumors". Hum. Pathol. 39 (3): 459–62. doi:10.1016/j.humpath.2007.08.010. PMID 18261631.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) - ^ Wong L, Hsu TH, Perlroth MG, Hofmann LV, Haynes CM, Katznelson L (2008). "Reninoma: case report and literature review". J. Hypertens. 26 (2): 368–73. doi:10.1097/HJH.0b013e3282f283f3. PMID 18192852.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) - ^ Martin SA, Mynderse LA, Lager DJ, Cheville JC; Martin; Lager; Cheville (2001). "Juxtaglomerular cell tumor: a clinicopathologic study of four cases and review of the literature". Am. J. Clin. Pathol. 116 (6): 854–63. doi:10.1309/B10J-FKQ5-J7P8-WKU4. PMID 11764074.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) - ^ Abbi RK, McVicar M, Teichberg S, Fish L, Kahn E (1993). "Pathologic characterization of a renin-secreting juxtaglomerular cell tumor in a child and review of the pediatric literature". Pediatr Pathol. 13 (4): 443–51. doi:10.3109/15513819309048234. PMID 8372029.
{{cite journal}}: CS1 maint: multiple names: authors list (link)
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