KATNA1

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KATNA1
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases KATNA1
External IDs MGI: 1344353 HomoloGene: 56014 GeneCards: KATNA1
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001204076
NM_007044

NM_011835

RefSeq (protein)

NP_001191005
NP_008975

n/a

Location (UCSC) Chr 6: 149.59 – 149.65 Mb Chr 10: 7.73 – 7.76 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Katanin p60 ATPase-containing subunit A1 is an enzyme that in humans is encoded by the KATNA1 gene.[3][4]

Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. This gene encodes the p80 subunit. This protein is a member of the AAA family of ATPases.[4]

References[edit]

Further reading[edit]