KDELR3

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KDELR3
Identifiers
Aliases KDELR3, ERD2L3, KDEL endoplasmic reticulum protein retention receptor 3
External IDs MGI: 2145953 HomoloGene: 68533 GeneCards: KDELR3
RNA expression pattern
PBB GE KDELR3 207265 s at fs.png

PBB GE KDELR3 204017 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_016657
NM_006855

NM_134090

RefSeq (protein)

NP_006846
NP_057839

NP_598851.2
NP_598851

Location (UCSC) Chr 22: 38.47 – 38.48 Mb Chr 15: 79.52 – 79.53 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

ER lumen protein retaining receptor 3 is a protein that in humans is encoded by the KDELR3 gene.[3]

Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, lys-asp-glu-leu (KDEL) in animal cells and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. KDELR3 was the third member of the family to be identified, and it encodes a protein highly homologous to KDELR1 and KDELR2 proteins. Two transcript variants of KDELR3 that arise by alternative splicing, and encode different isoforms of KDELR3 receptor, have been described.[3]

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