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KIN (gene)

From Wikipedia, the free encyclopedia
KIN
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesKIN, BTCD, KIN17, Rts2, Kin17 DNA and RNA binding protein
External IDsOMIM: 601720; MGI: 96676; HomoloGene: 8196; GeneCards: KIN; OMA:KIN - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_012311

NM_025280

RefSeq (protein)

NP_036443

NP_079556

Location (UCSC)Chr 10: 7.75 – 7.79 MbChr 2: 10.09 – 10.1 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

DNA/RNA-binding protein KIN17 is a protein that in humans is encoded by the KIN gene.[5][6]

The protein encoded by this gene is a nuclear protein that forms intranuclear foci during proliferation and is redistributed in the nucleoplasm during the cell cycle. Short-wave ultraviolet light provokes the relocalization of the protein, suggesting its participation in the cellular response to DNA damage. Originally selected based on protein-binding with RecA antibodies, the mouse protein presents a limited similarity with a functional domain of the bacterial RecA protein, a characteristic shared by this human ortholog.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000151657Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037262Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Angulo JF, Rouer E, Mazin A, Mattei MG, Tissier A, Horellou P, Benarous R, Devoret R (Nov 1991). "Identification and expression of the cDNA of KIN17, a zinc-finger gene located on mouse chromosome 2, encoding a new DNA-binding protein". Nucleic Acids Res. 19 (19): 5117–23. doi:10.1093/nar/19.19.5117. PMC 328864. PMID 1923796.
  6. ^ a b "Entrez Gene: KIN KIN, antigenic determinant of recA protein homolog (mouse)".

Further reading

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[edit]
  • Overview of all the structural information available in the PDB for UniProt: O60870 (DNA/RNA-binding protein KIN17) at the PDBe-KB.