Importin subunit alpha-5

KPNA1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2JDQ, 3TJ3, 4B18
Identifiers
Aliases	KPNA1, IPOA5, NPI-1, RCH2, SRP1, Importin, Karyopherin alpha 1, karyopherin subunit alpha 1
External IDs	OMIM: 600686; MGI: 103560; HomoloGene: 55642; GeneCards: KPNA1; OMA:KPNA1 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	122,514,945 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	35,857,501 bp
RNA expression pattern
	Top expressed in
	glutes; ; biceps brachii; ; sural nerve; ; deltoid muscle; ; gastrocnemius muscle; ; endothelial cell; ; Skeletal muscle tissue of biceps brachii; ; Skeletal muscle tissue of rectus abdominis; ; triceps brachii muscle; ; tibialis anterior muscle;
	Top expressed in
	triceps brachii muscle; ; otic vesicle; ; gastrocnemius muscle; ; vastus lateralis muscle; ; muscle of thigh; ; extensor digitorum longus muscle; ; medial head of gastrocnemius muscle; ; temporal muscle; ; blood; ; sternocleidomastoid muscle;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; nuclear localization sequence binding; nuclear import signal receptor activity;
Cellular component	nuclear pore; nucleoplasm; dendrite; nucleus; cytoplasm; cytosol; host cell; postsynaptic density; glutamatergic synapse;
Biological process	regulation of DNA recombination; intracellular transport of virus; apoptotic DNA fragmentation; protein import into nucleus; protein transport; modulation by virus of host cellular process; NLS-bearing protein import into nucleus; viral process; postsynapse to nucleus signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	3836
	16646
	ENSG00000114030
	ENSMUSG00000022905
	P52294
	Q60960
	NM_002264
	NM_008465
	NP_002255
	NP_032491
	Wikidata
View/Edit Human	View/Edit Mouse

Importin subunit alpha-1 is a protein that in humans is encoded by the KPNA1 gene.^[5]

Interactions

Karyopherin alpha 1 has been shown to interact with KPNB1^[6]^[7] and UBR5.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000114030 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022905 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Cortes P, Ye ZS, Baltimore D (Sep 1994). "RAG-1 interacts with the repeated amino acid motif of the human homologue of the yeast protein SRP1". Proc Natl Acad Sci U S A. 91 (16): 7633–7. Bibcode:1994PNAS...91.7633C. doi:10.1073/pnas.91.16.7633. PMC 44456. PMID 8052633.
^ Köhler, M; Speck C; Christiansen M; Bischoff F R; Prehn S; Haller H; Görlich D; Hartmann E (Nov 1999). "Evidence for distinct substrate specificities of importin alpha family members in nuclear protein import". Mol. Cell. Biol. 19 (11). UNITED STATES: 7782–91. doi:10.1128/mcb.19.11.7782. ISSN 0270-7306. PMC 84838. PMID 10523667. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)
^ Percipalle, P; Clarkson W D; Kent H M; Rhodes D; Stewart M (Mar 1997). "Molecular interactions between the importin alpha/beta heterodimer and proteins involved in vertebrate nuclear protein import". J. Mol. Biol. 266 (4). ENGLAND: 722–32. doi:10.1006/jmbi.1996.0801. ISSN 0022-2836. PMID 9102465. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)
^ Henderson, Michelle J; Russell Amanda J; Hird Samantha; Muñoz Marcia; Clancy Jennifer L; Lehrbach Gillian M; Calanni Sophina T; Jans David A; Sutherland Robert L; Watts Colin K W (Jul 2002). "EDD, the human hyperplastic discs protein, has a role in progesterone receptor coactivation and potential involvement in DNA damage response". J. Biol. Chem. 277 (29). United States: 26468–78. doi:10.1074/jbc.M203527200. ISSN 0021-9258. PMID 12011095. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)CS1 maint: unflagged free DOI (link)

Interactions

References

Further reading