LHX2

LHX2
Identifiers
Aliases	LHX2, LH2, hLhx2, LIM homeobox 2
External IDs	OMIM: 603759; MGI: 96785; HomoloGene: 55848; GeneCards: LHX2; OMA:LHX2 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	124,033,301 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	38,259,745 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; hair follicle; ; ganglionic eminence; ; sperm; ; retinal pigment epithelium; ; endothelial cell; ; entorhinal cortex; ; middle temporal gyrus; ; Brodmann area 23; ; amygdala;
	Top expressed in
	ventricular zone; ; olfactory epithelium; ; ganglionic eminence; ; lip; ; dentate gyrus of hippocampal formation granule cell; ; septum transversum; ; barrel cortex; ; hand; ; hippocampus proper; ; hepatic diverticulum;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	metal ion binding; sequence-specific DNA binding; chromatin binding; DNA binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific; transcription factor binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding;
Cellular component	nucleus; intracellular anatomical structure;
Biological process	negative regulation of transcription regulatory region DNA binding; mesoderm development; telencephalon development; neural tube closure; retina development in camera-type eye; cerebral cortex development; transcription, DNA-templated; axon guidance; axon extension; hair follicle development; maintenance of epithelial cell apical/basal polarity; neurogenesis; brain development; olfactory bulb development; nervous system development; dorsal/ventral pattern formation; positive regulation of transcription, DNA-templated; regulation of transcription, DNA-templated; positive regulation of transcription by RNA polymerase II; neuron differentiation; anatomical structure formation involved in morphogenesis; telencephalon regionalization; transcription by RNA polymerase II; negative regulation of gene expression, epigenetic; negative regulation of neurogenesis; positive regulation of neural precursor cell proliferation;
	Sources:Amigo / QuickGO
Orthologs
	9355
	16870
	ENSG00000106689
	ENSMUSG00000000247
	P50458
	Q9Z0S2
	NM_004789
	NM_001290646; NM_010710
	NP_004780
	NP_001277575; NP_034840
	Wikidata
View/Edit Human	View/Edit Mouse

LIM/homeobox protein Lhx2 is a protein that in humans is encoded by the LHX2 gene.^[5]^[6]^[7]

Template:PBB Summary

Interactions

LHX2 has been shown to interact with CITED2.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000106689 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000000247 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wu HK, Heng HH, Siderovski DP, Dong WF, Okuno Y, Shi XM, Tsui LC, Minden MD (July 1996). "Identification of a human LIM-Hox gene, hLH-2, aberrantly expressed in chronic myelogenous leukaemia and located on 9q33-34.1". Oncogene. 12 (6): 1205–12. PMID 8649822.
^ Rincon-Limas DE, Lu CH, Canal I, Calleja M, Rodriguez-Esteban C, Izpisua-Belmonte JC, Botas J (April 1999). "Conservation of the expression and function of apterous orthologs in Drosophila and mammals". Proc Natl Acad Sci U S A. 96 (5): 2165–70. doi:10.1073/pnas.96.5.2165. PMC 26754. PMID 10051612.
^ "Entrez Gene: LHX2 LIM homeobox 2".
^ Glenn, D J; Maurer R A (December 1999). "MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression". J. Biol. Chem. 274 (51). UNITED STATES: 36159–67. doi:10.1074/jbc.274.51.36159. ISSN 0021-9258. PMID 10593900. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help)CS1 maint: unflagged free DOI (link)

Interactions

References

Further reading