LLGL1

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LLGL1
Identifiers
AliasesLLGL1, DLG4, HUGL, HUGL-1, HUGL1, LLGL, Lgl1, Mgl1, scribble cell polarity complex component
External IDsMGI: 102682 HomoloGene: 31220 GeneCards: LLGL1
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for LLGL1
Genomic location for LLGL1
Band17p11.2Start18,225,587 bp[1]
End18,244,875 bp[1]
RNA expression pattern
PBB GE LLGL1 206124 s at fs.png

PBB GE LLGL1 206123 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004140

NM_001159404
NM_001159405
NM_008502

RefSeq (protein)

NP_004131

NP_001152876
NP_001152877
NP_032528

Location (UCSC)Chr 17: 18.23 – 18.24 MbChr 11: 60.7 – 60.71 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Lethal(2) giant larvae protein homolog 1 is a protein that in humans is encoded by the LLGL1 gene.[5][6][7]

This gene encodes a protein that is similar to a tumor suppressor in Drosophila. The protein is part of a cytoskeletal network and is associated with nonmuscle myosin II heavy chain and a kinase that specifically phosphorylates this protein at serine residues. The gene is located within the Smith-Magenis syndrome region on chromosome 17.[7]

References[edit]

  1. ^ a b c ENSG00000131899 GRCh38: Ensembl release 89: ENSG00000284137, ENSG00000131899 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020536 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Strand D, Unger S, Corvi R, Hartenstein K, Schenkel H, Kalmes A, Merdes G, Neumann B, Krieg-Schneider F, Coy JF, et al. (Aug 1995). "A human homologue of the Drosophila tumour suppressor gene l(2)gl maps to 17p11.2-12 and codes for a cytoskeletal protein that associates with nonmuscle myosin II heavy chain". Oncogene. 11 (2): 291–301. PMID 7542763.
  6. ^ Koyama K, Fukushima Y, Inazawa J, Tomotsune D, Takahashi N, Nakamura Y (Mar 1996). "The human homologue of the murine Llglh gene (LLGL) maps within the Smith-Magenis syndrome region in 17p11.2". Cytogenet Cell Genet. 72 (1): 78–82. doi:10.1159/000134167. PMID 8565641.
  7. ^ a b "Entrez Gene: LLGL1 lethal giant larvae homolog 1 (Drosophila)".

Further reading[edit]