LPP (gene)

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LPP
Identifiers
Aliases LPP
External IDs MGI: 2441849 HomoloGene: 4075 GeneCards: 4026
Genetically Related Diseases
Disease Name References
obesity
Vitiligo
smallpox
coeliac disease
RNA expression pattern
PBB GE LPP 202821 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001167671
NM_001167672
NM_005578

NM_001145952
NM_001145954
NM_178665

RefSeq (protein)

NP_001161143.1
NP_005569.1

NP_001139424.1
NP_001139426.1
NP_848780.3

Location (UCSC) Chr 3: 188.15 – 188.89 Mb Chr 16: 24.39 – 24.99 Mb
PubMed search [5] [6]
Wikidata
View/Edit Human View/Edit Mouse

Lipoma-preferred partner is a protein that in humans is encoded by the LPP gene.[1][2]

Function[edit]

Lipoma-preferred partner is a subfamily of LIM domain proteins that are characterized by an N-terminal proline rich region and three C-terminal LIM domains. The encoded protein localizes to the cell periphery in focal adhesions and may be involved in cell-cell adhesion and cell motility. This protein also shuttles through the nucleus and may function as a transcriptional co-activator. This gene is located at the junction of certain disease related chromosomal translocations which result in the expression of fusion proteins that may promote tumor growth.[2]

References[edit]

  1. ^ Petit MM, Mols R, Schoenmakers EF, Mandahl N, Van de Ven WJ (Feb 1997). "LPP, the preferred fusion partner gene of HMGIC in lipomas, is a novel meo LOmber of the LIM protein gene family". Genomics 36 (1): 118–29. doi:10.1006/geno.1996.0432. PMID 8812423. 
  2. ^ a b "Entrez Gene: LPP LIM domain containing preferred translocation partner in lipoma". 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.