LPP (gene)

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Lua error in mw.wikibase.entity.lua at line 34: The entity data must be a table obtained via mw.wikibase.getEntityObject. Lipoma-preferred partner is a protein that in humans is encoded by the LPP gene.[1][2]

Function[edit]

Lipoma-preferred partner is a subfamily of LIM domain proteins that are characterized by an N-terminal proline rich region and three C-terminal LIM domains. The encoded protein localizes to the cell periphery in focal adhesions and may be involved in cell-cell adhesion and cell motility. This protein also shuttles through the nucleus and may function as a transcriptional co-activator. This gene is located at the junction of certain disease related chromosomal translocations which result in the expression of fusion proteins that may promote tumor growth.[2]

References[edit]

  1. ^ Petit MM, Mols R, Schoenmakers EF, Mandahl N, Van de Ven WJ (Feb 1997). "LPP, the preferred fusion partner gene of HMGIC in lipomas, is a novel meo LOmber of the LIM protein gene family". Genomics. 36 (1): 118–29. PMID 8812423. doi:10.1006/geno.1996.0432. 
  2. ^ a b "Entrez Gene: LPP LIM domain containing preferred translocation partner in lipoma". 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.