LPP (gene)

LPP
Identifiers
Aliases	LPP, LIM domain containing preferred translocation partner in lipoma
External IDs	OMIM: 600700; MGI: 2441849; HomoloGene: 4075; GeneCards: LPP; OMA:LPP - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	188,890,671 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	24,992,578 bp
RNA expression pattern
	Top expressed in
	saphenous vein; ; urethra; ; vena cava; ; nipple; ; pylorus; ; tail of epididymis; ; cardia; ; seminal vesicula; ; epithelium of colon; ; superficial temporal artery;
	Top expressed in
	ascending aorta; ; aortic valve; ; Paneth cell; ; umbilical cord; ; tunica media of zone of aorta; ; endothelial cell of lymphatic vessel; ; conjunctival fornix; ; urinary bladder; ; cervix; ; Ileal epithelium;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; metal ion binding;
Cellular component	cell junction; plasma membrane; membrane; nucleus; focal adhesion; cytoplasm; cytosol; stress fiber;
Biological process	cell adhesion; biological process; cell-cell adhesion;
	Sources:Amigo / QuickGO
Orthologs
	4026
	210126
	ENSG00000145012
	ENSMUSG00000033306
	Q93052
	Q8BFW7
NM_001167671; NM_001167672; NM_005578; NM_001375455; NM_001375456;
	NM_001375457; NM_001375458; NM_001375459; NM_001375460; NM_001375461; NM_001375462; NM_001375463; NM_001375464; NM_001375465
	NM_001145952; NM_001145954; NM_178665
NP_001161143; NP_001161144; NP_005569; NP_001362384; NP_001362385;
	NP_001362386; NP_001362387; NP_001362388; NP_001362389; NP_001362390; NP_001362391; NP_001362392; NP_001362393; NP_001362394
	NP_001139424; NP_001139426; NP_848780
	Wikidata
View/Edit Human	View/Edit Mouse

Lipoma-preferred partner is a protein that in humans is encoded by the LPP gene.^[5]^[6]

Function

Lipoma-preferred partner is a subfamily of LIM domain proteins that are characterized by an N-terminal proline rich region and three C-terminal LIM domains. The encoded protein localizes to the cell periphery in focal adhesions and may be involved in cell-cell adhesion and cell motility. This protein also shuttles through the nucleus and may function as a transcriptional co-activator. This gene is located at the junction of certain disease related chromosomal translocations which result in the expression of fusion proteins that may promote tumor growth.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000145012 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000033306 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Petit MM, Mols R, Schoenmakers EF, Mandahl N, Van de Ven WJ (Feb 1997). "LPP, the preferred fusion partner gene of HMGIC in lipomas, is a novel meo LOmber of the LIM protein gene family". Genomics. 36 (1): 118–29. doi:10.1006/geno.1996.0432. PMID 8812423.
^ ^a ^b "Entrez Gene: LPP LIM domain containing preferred translocation partner in lipoma".

Schoenmakers EF; Wanschura S; Mols R; et al. (1995). "Recurrent rearrangements in the high mobility group protein gene, HMGI-C, in benign mesenchymal tumours". Nat. Genet. 10 (4): 436–44. doi:10.1038/ng0895-436. PMID 7670494. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Petit MM, Swarts S, Bridge JA, Van de Ven WJ (1998). "Expression of reciprocal fusion transcripts of the HMGIC and LPP genes in parosteal lipoma". Cancer Genet. Cytogenet. 106 (1): 18–23. doi:10.1016/S0165-4608(98)00038-7. PMID 9772904.
Petit MM; Fradelizi J; Golsteyn RM; et al. (2000). "LPP, an Actin Cytoskeleton Protein Related to Zyxin, Harbors a Nuclear Export Signal and Transcriptional Activation Capacity". Mol. Biol. Cell. 11 (1): 117–29. doi:10.1091/mbc.11.1.117. PMC 14761. PMID 10637295. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Rogalla P, Lemke I, Kazmierczak B, Bullerdiek J (2001). "An identical HMGIC-LPP fusion transcript is consistently expressed in pulmonary chondroid hamartomas with t(3;12)(q27-28;q14-15)". Genes Chromosomes Cancer. 29 (4): 363–6. doi:10.1002/1098-2264(2000)9999:9999<1::AID-GCC1043>3.0.CO;2-N. PMID 11066083.
Harrington JJ; Sherf B; Rundlett S; et al. (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression". Nat. Biotechnol. 19 (5): 440–5. doi:10.1038/88107. PMID 11329013. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Dahéron L; Veinstein A; Brizard F; et al. (2001). "Human LPP gene is fused to MLL in a secondary acute leukemia with a t(3;11) (q28;q23)". Genes Chromosomes Cancer. 31 (4): 382–9. doi:10.1002/gcc.1157. PMID 11433529. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help); replacement character in |first6= at position 5 (help); replacement character in |first8= at position 5 (help)
Lemke I, Rogalla P, Bullerdiek J (2002). "A novel LPP fusion gene indicates the crucial role of truncated LPP proteins in lipomas and pulmonary chondroid hamartomas". Cytogenet. Cell Genet. 95 (3–4): 153–6. doi:10.1159/000059338. PMID 12063392.
Petit MM, Meulemans SM, Van de Ven WJ (2003). "The focal adhesion and nuclear targeting capacity of the LIM-containing lipoma-preferred partner (LPP) protein". J. Biol. Chem. 278 (4): 2157–68. doi:10.1074/jbc.M206106200. PMID 12441356.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Lemke I; Rogalla P; Grundmann F; et al. (2003). "Expression of the HMGA2-LPP fusion transcript in only 1 of 61 karyotypically normal pulmonary chondroid hamartomas". Cancer Genet. Cytogenet. 138 (2): 160–4. doi:10.1016/S0165-4608(02)00595-2. PMID 12505264. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Salomon AR; Ficarro SB; Brill LM; et al. (2003). "Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry". Proc. Natl. Acad. Sci. U.S.A. 100 (2): 443–8. doi:10.1073/pnas.2436191100. PMC 141014. PMID 12522270. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Li B, Zhuang L, Reinhard M, Trueb B (2003). "The lipoma preferred partner LPP interacts with alpha-actinin". J. Cell. Sci. 116 (Pt 7): 1359–66. doi:10.1242/jcs.00309. PMID 12615977.
Gorenne I; Nakamoto RK; Phelps CP; et al. (2003). "LPP, a LIM protein highly expressed in smooth muscle". Am. J. Physiol., Cell Physiol. 285 (3): C674–85. doi:10.1152/ajpcell.00608.2002. PMID 12760907. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Brill LM; Salomon AR; Ficarro SB; et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Rush J; Moritz A; Lee KA; et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Petit MM; Meulemans SM; Alen P; et al. (2006). "The tumor suppressor Scrib interacts with the zyxin-related protein LPP, which shuttles between cell adhesion sites and the nucleus". BMC Cell Biol. 6: 1. doi:10.1186/1471-2121-6-1. PMC 546208. PMID 15649318. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)CS1 maint: unflagged free DOI (link)
Zhang Y; Wolf-Yadlin A; Ross PL; et al. (2005). "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules". Mol. Cell Proteomics. 4 (9): 1240–50. doi:10.1074/mcp.M500089-MCP200. PMID 15951569. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)CS1 maint: unflagged free DOI (link)
Tao WA; Wollscheid B; O'Brien R; et al. (2005). "Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry". Nat. Methods. 2 (8): 591–8. doi:10.1038/nmeth776. PMID 16094384. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
von Ahsen I, Rogalla P, Bullerdiek J (2006). "Expression patterns of the LPP-HMGA2 fusion transcript in pulmonary chondroid hamartomas with t(3;12)(q27 approximately 28;q14 approximately 15)". Cancer Genet. Cytogenet. 163 (1): 68–70. doi:10.1016/j.cancergencyto.2005.02.023. PMID 16271958.
Kubo T; Matsui Y; Goto T; et al. (2006). "Overexpression of HMGA2-LPP fusion transcripts promotes expression of the alpha 2 type XI collagen gene". Biochem. Biophys. Res. Commun. 340 (2): 476–81. doi:10.1016/j.bbrc.2005.12.042. PMID 16375854. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000145012 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000033306 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8812423-5] Petit MM, Mols R, Schoenmakers EF, Mandahl N, Van de Ven WJ (Feb 1997). "LPP, the preferred fusion partner gene of HMGIC in lipomas, is a novel meo LOmber of the LIM protein gene family". Genomics. 36 (1): 118–29. doi:10.1006/geno.1996.0432. PMID 8812423.

[entrez-6] "Entrez Gene: LPP LIM domain containing preferred translocation partner in lipoma".

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Function

References

Further reading