LRIG1

LRIG1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4U7L, 4U7M
Identifiers
Aliases	LRIG1, LIG-1, LIG1, leucine-rich repeats and immunoglobulin like domains 1, leucine rich repeats and immunoglobulin like domains 1
External IDs	OMIM: 608868; MGI: 107935; HomoloGene: 7380; GeneCards: LRIG1; OMA:LRIG1 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	66,501,263 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	94,677,139 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; bronchial epithelial cell; ; ventricular zone; ; body of pancreas; ; cardia; ; gastric mucosa; ; muscle layer of sigmoid colon; ; pylorus; ; internal globus pallidus; ; lactiferous duct;
	Top expressed in
	muscle of thigh; ; lip; ; ventricular zone; ; dentate gyrus of hippocampal formation granule cell; ; cerebellar cortex; ; zygote; ; secondary oocyte; ; superior frontal gyrus; ; tail of embryo; ; esophagus;
	More reference expression data
	More reference expression data
Orthologs
	26018
	16206
	ENSG00000144749
	ENSMUSG00000030029
	Q96JA1
	P70193
	NM_015541
	NM_008377; NM_001355269
NP_056356; NP_001364273; NP_001364274; NP_001364275; NP_001364276;
	NP_001364277; NP_001364278
	NP_032403; NP_001342198
	Wikidata
View/Edit Human	View/Edit Mouse

Leucine-rich repeats and immunoglobulin-like domains protein 1 is a protein that in humans is encoded by the LRIG1 gene.^[5]^[6]^[7] It encodes a transmembrane protein that has been shown to interact with receptor tyrosine kinases of the EGFR-family^[8] , MET^[9] and RET.^[10] Template:PBB Summary

Model organisms

*Lrig1* knockout mouse phenotype
Characteristic	Phenotype
Homozygote viability	Normal
Fertility	Normal
Body weight	Abnormal^[11]
Anxiety	Normal
Neurological assessment	Normal
Grip strength	Normal
Hot plate	Normal
Dysmorphology	Abnormal^[12]
Indirect calorimetry	Normal
Glucose tolerance test	Normal
Auditory brainstem response	Abnormal
DEXA	Abnormal^[13]
Radiography	Abnormal^[14]
Body temperature	Normal
Eye morphology	Normal
Clinical chemistry	Abnormal^[15]
Plasma immunoglobulins	Normal
Haematology	Normal
Micronucleus test	Normal
Heart weight	Normal
Tail epidermis wholemount	Abnormal
Skin Histopathology	Abnormal
Eye Histopathology	Normal
Salmonella infection	Abnormal^[16]
Citrobacter infection	Abnormal^[17]
All tests and analysis from^[18]^[19]

Model organisms have been used in the study of LRIG1 function. A conditional knockout mouse line, called Lrig1^{tm1a(EUCOMM)Wtsi}^[20]^[21] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.^[22]^[23]^[24]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.^[18]^[25] Twenty five tests were carried out on homozygous mutant mice and ten significant abnormalities were observed, including decreased body weight and total body fat, scaly skin, abnormal hair shedding, a moderate degree of hearing impairment, vertebral fusion, abnormal plasma chemistry and an increased susceptibility to bacterial infection (with both Salmonella and Citrobacter).^[18]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000144749 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030029 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nilsson J, Vallbo C, Guo D, Golovleva I, Hallberg B, Henriksson R, Hedman H (Jun 2001). "Cloning, characterization, and expression of human LIG1". Biochem Biophys Res Commun. 284 (5): 1155–61. doi:10.1006/bbrc.2001.5092. PMID 11414704.
^ Hedman H, Nilsson J, Guo D, Henriksson R (Sep 2002). "Is LRIG1 a tumour suppressor gene at chromosome 3p14.3?". Acta Oncol. 41 (4): 352–4. doi:10.1080/028418602760169398. PMID 12234026.
^ "Entrez Gene: LRIG1 leucine-rich repeats and immunoglobulin-like domains 1".
^ Gur G; Rubin C; Katz M; et al. (2005). "LRIG1 restricts growth factor signaling by enhancing receptor ubiquitylation and degradation". EMBO J. 23 (16): 3270–81. doi:10.1038/sj.emboj.7600342. PMC 514515. PMID 15282549. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
^ Shattuck DL; Miller JK; Laederich M; et al. (2007). "LRIG1 Is a Novel Negative Regulator of the Met Receptor and Opposes Met and Her2 Synergy". Mol. Cell. Biol. 27 (5): 1934–46. doi:10.1128/MCB.00757-06. PMC 1820466. PMID 17178829. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
^ Ledda F, Bieraugel O, Fard SS, Vilar M, Paratcha G (2008). "Lrig1 is an endogenous inhibitor of Ret receptor tyrosine kinase activation, downstream signaling, and biological responses to GDNF". J. Neurosci. 28 (2): 39–49. doi:10.1523/JNEUROSCI.2196-07.2008. PMID 18171921.
^ "Body weight data for Lrig1". Wellcome Trust Sanger Institute.
^ "Dysmorphology data for Lrig1". Wellcome Trust Sanger Institute.
^ "DEXA data for Lrig1". Wellcome Trust Sanger Institute.
^ "Radiography data for Lrig1". Wellcome Trust Sanger Institute.
^ "Clinical chemistry data for Lrig1". Wellcome Trust Sanger Institute.
^ "Salmonella infection data for Lrig1". Wellcome Trust Sanger Institute.
^ "Citrobacter infection data for Lrig1". Wellcome Trust Sanger Institute.
^ ^a ^b ^c Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x.
^ Mouse Resources Portal, Wellcome Trust Sanger Institute.
^ "International Knockout Mouse Consortium".
^ "Mouse Genome Informatics".
^ Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–342. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
^ Dolgin E (2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
^ Collins FS, Rossant J, Wurst W (2007). "A Mouse for All Reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
^ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biol. 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.{{cite journal}}: CS1 maint: unflagged free DOI (link)

Model organisms

References

Further reading