LYK5

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STE20-related kinase adaptor alpha
PDB 1upk EBI.jpg
Rendering of STRADA from PDB 1UPK
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols STRADA ; LYK5; NY-BR-96; PMSE; STRAD; Stlk
External IDs OMIM608626 MGI1919399 HomoloGene12448 IUPHAR: 2227 ChEMBL: 1795198 GeneCards: STRADA Gene
RNA expression pattern
PBB GE LYK5 221554 at tn.png
PBB GE LYK5 52169 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 92335 72149
Ensembl ENSG00000266173 ENSMUSG00000069631
UniProt Q7RTN6 Q3UUJ4
RefSeq (mRNA) NM_001003786 NM_001252448
RefSeq (protein) NP_001003786 NP_001239377
Location (UCSC) Chr 17:
61.78 – 61.82 Mb
Chr 11:
106.16 – 106.2 Mb
PubMed search [1] [2]

Protein kinase LYK5, also known as LYK5 or STRADα, is a human protein and also denotes the gene encoding it.[1][2]

Function[edit]

Endogenous LKB1 and STRADα form a complex in which STRADα activates LKB1, resulting in phosphorylation of both partners. Removal of endogenous LYK5 by small interfering RNA abrogates LKB1-induced G1 phase arrest.[2] STRADα stabilizes LKB1 protein both in vivo and in vitro, and is capable of eliciting multiple axons in mouse embryonic cortical cultured neurons when overexpressed with LKB1. STRADα is highly spliced in vivo, and this is both developmentally regulated and tissue-specific, but the unique functions of the splice variants are not yet understood.[3]

Disease linkage[edit]

Mutations in the LYK5/STRADα gene are associated with polyhydramnios, megalencephaly and symptomatic epilepsy (collectively known as the PMSE syndrome).[4]

Interactions[edit]

STRADα has been shown to interact with LKB1 and MO25.[2][5]

References[edit]

  1. ^ "Entrez Gene: LYK5 protein kinase LYK5". 
  2. ^ a b c Baas AF, Boudeau J, Sapkota GP, Smit L, Medema R, Morrice NA et al. (June 2003). "Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD". EMBO J. 22 (12): 3062–72. doi:10.1093/emboj/cdg292. PMC 162144. PMID 12805220. 
  3. ^ Veleva-Rotse BO, Smart JL, Baas AF, Edmonds B, Zhao ZM, Brown A et al. (2014). "STRAD pseudokinases regulate axogenesis and LKB1 stability.". Neural Dev 9 (5). doi:10.1186/1749-8104-9-5. PMID 24594058. /
  4. ^ Puffenberger EG, Strauss KA, Ramsey KE, Craig DW, Stephan DA, Robinson DL et al. (July 2007). "Polyhydramnios, megalencephaly and symptomatic epilepsy caused by a homozygous 7-kilobase deletion in LYK5". Brain 130 (Pt 7): 1929–41. doi:10.1093/brain/awm100. PMID 17522105. 
  5. ^ Boudeau J, Scott JW, Resta N, Deak M, Kieloch A, Komander D et al. (Dec 2004). "Analysis of the LKB1-STRAD-MO25 complex". J. Cell. Sci. 117 (Pt 26): 6365–75. doi:10.1242/jcs.01571. PMID 15561763. 

Further reading[edit]