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LYK5

From Wikipedia, the free encyclopedia
STRADA
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSTRADA, LYK5, NY-BR-96, PMSE, STRAD, Stlk, STE20-related kinase adaptor alpha, STRAD alpha, STE20 related adaptor alpha
External IDsOMIM: 608626; MGI: 1919399; HomoloGene: 12448; GeneCards: STRADA; OMA:STRADA - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001252448
NM_001252449
NM_028126

RefSeq (protein)

NP_001239377
NP_001239378
NP_082402

Location (UCSC)Chr 17: 63.68 – 63.74 MbChr 11: 106.05 – 106.09 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein kinase LYK5, also known as LYK5 or STRADα, is a human protein and also denotes the gene encoding it.[5][6]

Function

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Endogenous LKB1 and STRADα form a complex in which STRADα activates LKB1, resulting in phosphorylation of both partners. Removal of endogenous LYK5 by small interfering RNA abrogates LKB1-induced G1 phase arrest.[6] STRADα stabilizes LKB1 protein both in vivo and in vitro, and is capable of eliciting multiple axons in mouse embryonic cortical cultured neurons when overexpressed with LKB1. STRADα is highly spliced in vivo,[7] and this is both developmentally regulated and tissue-specific, but the unique functions of the splice variants are not yet understood.[8]

Disease linkage

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Mutations in the LYK5/STRADα gene are associated with polyhydramnios, megalencephaly and symptomatic epilepsy (collectively known as the PMSE syndrome).[9]

Interactions

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STRADα has been shown to interact with LKB1 and MO25.[6][10]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000266173Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000069631Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: LYK5 protein kinase LYK5".
  6. ^ a b c Baas AF, Boudeau J, Sapkota GP, Smit L, Medema R, Morrice NA, Alessi DR, Clevers HC (June 2003). "Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD". EMBO J. 22 (12): 3062–72. doi:10.1093/emboj/cdg292. PMC 162144. PMID 12805220.
  7. ^ Marignani, Paola A.; Scott, Kristine; Bagnulo, Rosanna; Cannone, Domenico; Ferrari, Eleonora; Stella, Alessandro; Guanti, Ginevra; Simone, Cristiano; Resta, Nicoletta (October 2007). "Novel splice isoforms of STRADα differentially affect LKB1 activity, complex assembly and subcellular localization". Cancer Biology & Therapy. 6 (10): 1627–1631. doi:10.4161/cbt.6.10.4787. ISSN 1538-4047. PMID 17921699.
  8. ^ Veleva-Rotse BO, Smart JL, Baas AF, Edmonds B, Zhao ZM, Brown A, Klug LR, Hansen K, Reilly G, Gardner AP, Subbiah K, Gaucher EA, Clevers H, Barnes AP (2014). "STRAD pseudokinases regulate axogenesis and LKB1 stability". Neural Dev. 9 (5): 5. doi:10.1186/1749-8104-9-5. PMC 4016016. PMID 24594058./
  9. ^ Puffenberger EG, Strauss KA, Ramsey KE, Craig DW, Stephan DA, Robinson DL, Hendrickson CL, Gottlieb S, Ramsay DA, Siu VM, Heuer GG, Crino PB, Morton DH (July 2007). "Polyhydramnios, megalencephaly and symptomatic epilepsy caused by a homozygous 7-kilobase deletion in LYK5". Brain. 130 (Pt 7): 1929–41. doi:10.1093/brain/awm100. PMID 17522105.
  10. ^ Boudeau J, Scott JW, Resta N, Deak M, Kieloch A, Komander D, Hardie DG, Prescott AR, van Aalten DM, Alessi DR (Dec 2004). "Analysis of the LKB1-STRAD-MO25 complex". J. Cell Sci. 117 (Pt 26): 6365–75. doi:10.1242/jcs.01571. PMID 15561763.

Further reading

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