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LYPLA3

From Wikipedia, the free encyclopedia
PLA2G15
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPLA2G15, ACS, GXVPLA2, LLPL, LPLA2, LYPLA3, phospholipase A2 group XV
External IDsOMIM: 609362; MGI: 2178076; HomoloGene: 8200; GeneCards: PLA2G15; OMA:PLA2G15 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_012320
NM_001363551

NM_133792
NM_001357319

RefSeq (protein)

NP_036452
NP_001350480

NP_598553
NP_001344248

Location (UCSC)Chr 16: 68.25 – 68.26 MbChr 8: 106.88 – 106.89 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

LYPLA3, also known as Group XV phospholipase A2, is an enzyme that in humans is encoded by the PLA2G15 gene.[5][6][7]

Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene hydrolyzes lysophosphatidylcholine to glycerophosphorylcholine and a free fatty acid. This enzyme is present in the plasma and thought to be associated with high-density lipoprotein. A later paper contradicts the function of this gene. It demonstrates that this gene encodes a lysosomal enzyme instead of a lysophospholipase and has both calcium-independent phospholipase A2 and transacylase activities.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000103066Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031903Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Taniyama Y, Shibata S, Kita S, Horikoshi K, Fuse H, Shirafuji H, Sumino Y, Fujino M (May 1999). "Cloning and expression of a novel lysophospholipase which structurally resembles lecithin cholesterol acyltransferase". Biochem Biophys Res Commun. 257 (1): 50–6. doi:10.1006/bbrc.1999.0411. PMID 10092508.
  6. ^ Schaloske RH, Dennis EA (Nov 2006). "The phospholipase A2 superfamily and its group numbering system". Biochim Biophys Acta. 1761 (11): 1246–59. doi:10.1016/j.bbalip.2006.07.011. PMID 16973413.
  7. ^ a b "Entrez Gene: LYPLA3 lysophospholipase 3 (lysosomal phospholipase A2)".

Further reading

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