Jump to content

Laurie Glimcher

From Wikipedia, the free encyclopedia

This is an old revision of this page, as edited by 156.111.216.131 (talk) at 18:04, 4 March 2016 (The paragraph led the reader to believe that Glimcher was directly involved in the research on the chimpanzees, and misattributed the decision directly to Glimcher.). The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.

Laurie H. Glimcher is an American physician-scientist and dean of Weill Cornell Medical College. She succeeded Antonio M. Gotto Jr. in January 2012.[1] She is also a member of the National Academy of Sciences.

Prior to her joining Weill Cornell, Glimcher was the Irene Heinz Given Professor of Immunology at the Harvard School of Public Health, and a professor of medicine at Harvard Medical School.[2] Clinically, she is a specialist in osteoporosis.[1] She received her bachelor's degree at Radcliffe College in 1972 and her M.D. at Harvard Medical School in 1976.

Her research, according to her biography at Harvard, "uses biochemical and genetic approaches to elucidate the molecular pathways that regulate CD4 T helper cell development and activation. ... The Glimcher laboratory defined the genetic bases of both IL-4 and IFNg expression in T cells. They identified the proto-oncogene c-maf as the transcription factor responsible for Th2-specific IL-4 expression [and]...discovered the first Th1-specific transcription factor, T-bet and demonstrated that this single factor is a master-regulator of IFNg gene expression and the Th1 phenotype." [2]

She is reported by the Chronicle of Higher Education to have " extensive ties to two pharmaceutical companies, Merck and Bristol-Myers Squibb.[1][3] According to the New York Times, since 1997 she has been on the Board of Bristol-Myers Squibb, and "received $244,500 in compensation for 2010" and "1.4 million in deferred share units" [1] Her research at Harvard has been partially funded by a three-year contract with Merck, "the company that makes Fosamax".[1] She is also on the Board of the Waters Corporation, a lab equipment manufacturer.[1] In this article, she "defended her outside interests, saying they presented no conflict as long as they were transparent. She said she wanted to 'leverage the strengths of everyone,' whether scientists, pharmaceutical companies or biotechnology companies. 'There should be no silos between all of these different strengths,' " [1]

Glimcher became the object of protests in the fall of 2015, which aimed to hold her responsible for a New York Blood Center decision to defund a primate research center in Liberia. Protestors argued that this resulted in the abandonment of 66 chimpanzees that had been research subjects there. Primatologist Jane Goodall became visibly involved in the protest. Glimcher left the NYBC board at the conclusion of her two year term at around the same time.[4]

On February 23, 2016 Glimcher was named the next President and CEO of Dana-Farber Cancer Institute to begin in January 2017, succeeding Dr. Edward J. Benz.

Memberships

Awards

  • Leukemia Society Stohlman Memorial Scholar Award,
  • Arthritis Foundation's Lee S. Howley Award, the
  • FASEB Excellence in Science Award,
  • American Society for Clinical Investigation Award,
  • Klemperer Award, the
  • AAUW Senior Scholar
  • Huang Meritorious Career Award,
  • American College of Rheumatology Distinguished Investigator.

She was honored by a symposium at Harvard on April 15, 2011, titled " “A Commitment to Lineage: A Symposium in Celebration of Laurie Glimcher,.[5]

Protests

In May 2015, because of her role on the board of the New York Blood Center, concerned New Yorkers began protesting at the Cornell Medical School the neglect of 66 chimpanzees in Liberia abandoned by Dr. Glimcher with no food or water. The protests continue.[6][7]

Selected recent publications

jointly with other members of her laboratory:

  • Ho I-C, Hodge MR, Rooney JW, Glimcher LH (1996). "The proto-oncogene c-maf is responsible for tissue-specific expression of interleukin-4". Cell. 85 (7): 973–83. doi:10.1016/S0092-8674(00)81299-4.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  • Kim JI, Li T, Ho IC, Grusby MJ, Glimcher LH (1999). "Requirement for the c-Maf transcription factor in crystallin gene regulation and lens development". Proc Natl Acad Sci USA. 96 (7): 3781–5. doi:10.1073/pnas.96.7.3781. PMID 10097114.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  • Kim JI, Ho IC, Grusby MJ, Glimcher LH (1999). "The transcription factor c-Maf controls the production of interleukin-4 but not other Th2 cytokines". Immunity. 10 (6): 745–51. doi:10.1016/s1074-7613(00)80073-4. PMID 10403649.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  • Szabo SJ, Kim ST, Costa GL, Zhang X, Fathman GC, Glimcher LH (2000). "A novel transcription factor, T-bet, directs Th1 lineage commitment". Cell. 100 (6): 655–69. doi:10.1016/S0092-8674(00)80702-3. PMID 10761931.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  • Reimold AM, Iwakoshi NN, Manis J, Vallabhajosyula P, Szomolanyi-Tsuda E, Gravallese EM, Friend D, Grusby MJ, Alt F; et al. (2001). "Plasma cell differentiation requires transcription factor XBP-1". Nature. 412 (6844): 300–7. doi:10.1038/35085509.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  • Szabo SJ, Sullivan BM, Stemmann C, Satoskar AR, Sleckman BP, Glimcher LH (2002). "Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells". Science. 295 (5553): 338–42. doi:10.1126/science.1065543.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  • Finotto S, Neurath MF, Glickman JN, Qin S, Lehr HA, Green FH, Ackerman K, Haley K, Galle PR; et al. (2002). "Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet". Science. 295 (5553): 336–8. doi:10.1126/science.1065544. PMID 11786643.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  • Maldonado RA, Irvine DJ, Schreiber R, Glimcher LH (2004). "A role for the immunological synapse in lineage commitment of CD4 lymphocytes". Nature. 431 (7008): 527–32. doi:10.1038/nature02916. PMID 15386021.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  • Hwang ES, Szabo SJ, Schwartzberg PL, Glimcher LH (2005). "T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3". Science. 307 (5708): 430–3. doi:10.1126/science.1103336. PMID 15662016.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  • Wang J, Fathman JW, Lugo-Villarino G, von Andrian U, Dorfman DM, Glimcher LH (2006). "Transcription factor T-bet regulates inflammatory arthritis through its function in dendritic cells". Journal of Clinical Investigation. 16 (2): 414–21.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  • Jones DC, Wein MN, Oukka M, Hofstaetter JG, Glimcher MJ, Glimcher LH (2006). "Regulation of adult bone mass by the zinc finger adapter protein Schnurri-3". Science. 312 (5777): 1223–7. doi:10.1126/science.1126313. PMID 16728642.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  • Garrett W, Lord GM, Punit S, Lugo G, Mazmanian S, Ito S, Glickman J, Glimcher LH (2007). "Communicable ulcerative colitis induced by T-bet deficiency in the innate immune system". Cell. 131 (1): 33–45. doi:10.1016/j.cell.2007.08.017. PMC 2169385. PMID 17923086.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  • Ah Lee, Scapa EF, Cohen DE, Glimcher LH (2008). "Regulation of hepatic lipogenesis by the transcription factor XBP1". Science. 320 (5882): 1492–6. doi:10.1126/science.1158042. PMID 18556558.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  • Kaser A, Lee AH, Franke A, Glickman JN, Zeissig S, Tilg H, Nieuwenhuis EES, Higgins DE, Schreiber S; et al. (2008). "Transcription factor XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease". Cell. 134 (5): 743–56. doi:10.1016/j.cell.2008.07.021. PMC 2586148. PMID 18775308.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  • Garrett W, Punit S, Gallini C, Michaud M, Zhang D, Sigrist K, Lord G, Glickman J, Glimcher LH.; et al. (2009). "Colitis-associated colorectal cancer driven by T-bet deficiency in dendritic cells". Cancer Cell. 16 (3): 208–19. doi:10.1016/j.ccr.2009.07.015.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  • Hetz C, Thielen P, Matus S, Nassif M, Court F, María Cuervo AM, Martinez G, Kiffin R, Brown R; et al. (2009). "XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy". Genes & Development. 23 (19): 2294–306. doi:10.1101/gad.1830709. PMC 2758741. PMID 19762508.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  • Garrett WS, Gordon J, Glimcher LH (2010). "Homeostasis and inflammation in the Intestine". Cell. 140 (6): 859–70. doi:10.1016/j.cell.2010.01.023. PMC 2845719. PMID 20303876.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  • Greenblatt MB, Shim JH, Zou W, Sitara D, Schweitzer M, Hu D, Lotinun S, Sano Y, Baron R; et al. (2010). "A p 38 MAPK pathway essential for bone homeostasis". Journal of Clinical Investigation. 120 (7): 2457–73. doi:10.1172/JCI42285. PMC 2898605. PMID 20551513.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  • Garrett WS, Gallini CA, Yatsunenko T, Michaud M, DuBois A, Delaney ML, Punit S, Karlsson M, Bry L, Glickman JN, Gordon JI, Onderdonk AB, Glimcher LH. 2010. Enterobacteriaceae act in concert with a gut microbiota to induce both spontaneous and maternally-transmitted colitis. Cell Host Microbe (in press).

References

  1. ^ a b c d e f g Hartocollis, Anemona (September 7, 2011). "Harvard Researcher Chosen as New Dean of Weill Cornell Medical College". The New York Times. Retrieved September 9, 2011.
  2. ^ a b official p. at Harvard
  3. ^ "New Dean of Weill Cornell Medical College Calls for Stronger Ties to Industry". Chronicle of Higher Education. September 8, 2011. Retrieved September 9, 2011.
  4. ^ "Weill Cornell Medicine Dean Accused of Chimp Abandonment". The Cornell Daily Sun. October 29, 2015. Retrieved November 6, 2015.
  5. ^ "HSPH's Laurie Glimcher Honored at Day-Long Symposium". Harvard School of Public Health. Retrieved September 9, 2011.
  6. ^ Protest at Cornell against NYBC's Laurie Glimcher, Videos by TheirTurn.net
  7. ^ New York Blood Center Abandons 66 Chimps, Leaving Them To Die of Starvation, May 28, 2015, Donny Moss, TheirTurn.net

Template:Persondata

Retrieved from "https://en.wikipedia.org/w/index.php?title=Laurie_Glimcher&oldid=708280707"