Locusta or Lucusta (d. 69), was a notorious maker of poisons in the 1st-century Roman Empire, active in the final two reigns of the Julio-Claudian dynasty. She supposedly took part in the assassinations of Claudius and Britannicus. She was a favourite of emperor Nero for several years, and Nero had her provide training to other poisoners in his service. Following Nero's death, Locusta was executed by his successor, Galba (reigned 68-69).
Locusta's career is described by the ancient historians Tacitus (Annals 12.66 and 13.15), Suetonius (Life of Nero, 33 and 47), and Cassius Dio (61.34 and 63.3). Juvenal also mentions Locusta in Book 1, line 71 of his Satires.
Locusta served as a poisons expert under empress Agrippina the Younger. In AD 54, already notorious and imprisoned on poisoning charges, Locusta was ordered by the empress Agrippina the Younger to supply a poison for the murder of her husband, Claudius. This was sprinkled on a mushroom and given to the emperor by his food-taster Halotus; when this poison appeared to be ineffectual, the doctor Gaius Stertinius Xenophon murdered Claudius with a poisoned feather ostensibly put down his throat to induce vomiting.
She reportedly advised Agrippina to use Atropa belladonna as a poison. Extracts of atropa have been used for poisoning since antiquity, as the plant and its fruits contain tropane alkaloids (primarily hyoscyamine and scopolamine). Atropa-derived poisons were commonly used in ancient Roman murders, and previous empress Livia reportedly used them to murder her contemporaries. The effective doses of atropa needed to cause hallucinations for up to four days, and the ones needed to kill a person were described by a 1st-century writer, Pedanius Dioscorides. Dioscorides called the plant "strychnos manikos" or "thryon". 
In AD 55, while still imprisoned, Locusta was called upon by Agrippina's son, the emperor Nero, to concoct a poison to murder Claudius' son Britannicus. When this poison was slow to work, Nero flogged Locusta with his own hand and threatened her with immediate execution, whereupon she supplied a quicker-acting poison that succeeded. Nero rewarded Locusta with a full pardon and large country estates where he sent pupils to learn her craft. Before Nero fled Rome in AD 68, he acquired poison from Locusta for his own use and kept it in a golden box. He eventually died by other means.
After Nero's suicide, Locusta was condemned to die by the emperor Galba during his brief reign, which ended 15 January AD 69. Along with Nero's favorites Helius, Patrobius, Narcissus and "others of the scum that had come to the surface in Nero's day", she was led in chains through the city and executed.
Locusta was one of the characters depicted in the historical film Humanity Through the Ages (1908) by director Georges Méliès. The film was an episodic depiction of humanity's brutality throughout its history, and the historic episodes depicted were chosen because they involved fratricide, murders, religious persecution, physical abuse and public humiliation, prisons and executions of prisoners, torture, and violent criminal subcultures. The film is thought to be among the lost films from its era.
- Juvenal (1839). Juvenal and Persius, Volume 1. Martin Madan (trans.). J. Vincent. p. 21.
- Scholiast on Juvenal 1.71.
- Tacitus, Annals 12.66-67; Cassius Dio 61.34.
- Michael (1998). Alkaloids : biochemistry, ecology, and medicinal applications. New York: Plenum Press. p. 20. ISBN 0-306-45465-3.
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- Suetonius, Nero 33; Tacitus, Annals 13.15.
- Suetonius, Nero 47.
- Cassius Dio 63.3
- Juvenal, Satires 1.71.
- Dumas, Alexandre. The Count of Monte Cristo. Oxford, GBR: Oxford University Press, UK, 2008. ProQuest ebrary. Web. 10 November 2015.
- Malthête, Jacques; Mannoni, Laurent (2008). L'oeuvre de Georges Méliès. Paris: Éditions de La Martinière. p. 229. ISBN 9782732437323.
- Frazer, John (1979). Artificially Arranged Scenes: The Films of Georges Méliès. Boston: G. K. Hall & Co. p. 191. ISBN 0816183686.
- Malthête, Jacques; Mannoni, Laurent (2008). L'oeuvre de Georges Méliès. Paris: Éditions de La Martinière. p. 228. ISBN 9782732437323.