MAP2K1IP1

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LAMTOR3
Protein MAP2K1IP1 PDB 1sko.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases LAMTOR3, MAP2K1IP1, MAPBP, MAPKSP1, MP1, PRO0633, Ragulator3, late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
External IDs MGI: 1929467 HomoloGene: 10539 GeneCards: LAMTOR3
RNA expression pattern
PBB GE MAP2K1IP1 217971 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001243736
NM_021970

NM_019920

RefSeq (protein)

NP_001230665
NP_068805

NP_064304.1
NP_064304

Location (UCSC) Chr 4: 99.88 – 99.89 Mb Chr 3: 137.92 – 137.93 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Mitogen-activated protein kinase scaffold protein 1 is a scaffold protein that in humans is encoded by the MAPKSP1 gene.[3][4][5]

Function[edit]

The protein encoded by this gene was identified as an interacting protein that binds specifically to MAP kinase kinase MAP2K1/MEK1 and to MAP kinase MAPK2/ERK1. This protein enhances the activation of MAPK2, and thus is thought to function as an adaptor to enhance the efficiency of the MAP kinase cascade.[5]

Interactions[edit]

MAP2K1IP1 has been shown to interact with MAP2K1.[3][6]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b Schaeffer HJ, Catling AD, Eblen ST, Collier LS, Krauss A, Weber MJ (Oct 1998). "MP1: a MEK binding partner that enhances enzymatic activation of the MAP kinase cascade". Science. 281 (5383): 1668–71. doi:10.1126/science.281.5383.1668. PMID 9733512. 
  4. ^ Lunin VV, Munger C, Wagner J, Ye Z, Cygler M, Sacher M (May 2004). "The structure of the MAPK scaffold, MP1, bound to its partner, p14. A complex with a critical role in endosomal map kinase signaling". J. Biol. Chem. 279 (22): 23422–30. doi:10.1074/jbc.M401648200. PMID 15016825. 
  5. ^ a b "Entrez Gene: MAP2K1IP1 mitogen-activated protein kinase kinase 1 interacting protein 1". 
  6. ^ Wunderlich W, Fialka I, Teis D, Alpi A, Pfeifer A, Parton RG, Lottspeich F, Huber LA (Feb 2001). "A novel 14-kilodalton protein interacts with the mitogen-activated protein kinase scaffold mp1 on a late endosomal/lysosomal compartment". J. Cell Biol. 152 (4): 765–76. doi:10.1083/jcb.152.4.765. PMC 2195784Freely accessible. PMID 11266467. 

Further reading[edit]