MED13

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MED13
Identifiers
Aliases MED13, ARC250, DRIP250, HSPC221, THRAP1, TRAP240, mediator complex subunit 13
External IDs MGI: 3029632 HomoloGene: 21067 GeneCards: MED13
Gene location (Human)
Chromosome 17 (human)
Chr. Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for MED13
Genomic location for MED13
Band 17q23.2 Start 61,942,605 bp[1]
End 62,065,282 bp[1]
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005121

NM_001080931

RefSeq (protein)

NP_005112

NP_001074400

Location (UCSC) Chr 17: 61.94 – 62.07 Mb Chr 11: 86.27 – 86.36 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Mediator complex subunit 13 is a protein that in humans is encoded by the MED13 gene.[5][6]

Function[edit]

This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. The product of this gene is proposed to form a sub-complex with MED12, cyclin C, and CDK8 that can negatively regulate transactivation by mediator.[5]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000108510 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034297 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ a b "Entrez Gene: Mediator complex subunit 13". Retrieved 2012-05-11. 
  6. ^ Tuchin DA, Erve PR, Schumer W (1976). "Prevention of endotoxin--induced irreversible platelet aggregation in vitro". Surgical Forum. 27 (62): 22–3. PMID 1019863. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.