MED27

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
MED27
Identifiers
AliasesMED27, CRAP34, CRSP34, CRSP8, TRAP37, MED3, mediator complex subunit 27
External IDsOMIM: 605044 MGI: 1916225 HomoloGene: 3152 GeneCards: MED27
Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for MED27
Genomic location for MED27
Band9q34.13Start131,852,928 bp[1]
End132,079,867 bp[1]
RNA expression pattern
PBB GE CRSP8 51176 at fs.png

PBB GE CRSP8 221598 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001253881
NM_001253882
NM_004269

NM_001290489
NM_026896
NM_029615
NM_001290490

RefSeq (protein)

NP_001240810
NP_001240811
NP_004260

NP_001277418
NP_001277419
NP_081172
NP_083891

Location (UCSC)Chr 9: 131.85 – 132.08 MbChr 2: 29.35 – 29.52 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse
Med27
Identifiers
SymbolMed27
PfamPF11571
InterProIPR021627

Mediator of RNA polymerase II transcription subunit 27 is an enzyme that in humans is encoded by the MED27 gene.[5][6] It forms part of the Mediator complex.

The ubiquitous expression of Med27 mRNA suggests a universal requirement for Med27 in transcriptional initiation. Loss of Crsp34/Med27 decreases amacrine cell number, but increases the number of rod photoreceptor cells.[7]

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors.[6]

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000160563 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026799 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ryu S, Zhou S, Ladurner AG, Tjian R (Feb 1999). "The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1". Nature. 397 (6718): 446–50. doi:10.1038/17141. PMID 9989412.
  6. ^ a b "Entrez Gene: CRSP8 cofactor required for Sp1 transcriptional activation, subunit 8, 34kDa".
  7. ^ Dürr K, Holzschuh J, Filippi A, Ettl AK, Ryu S, Shepherd IT, Driever W (October 2006). "Differential roles of transcriptional mediator complex subunits Crsp34/Med27, Crsp150/Med14 and Trap100/Med24 during zebrafish retinal development". Genetics. 174 (2): 693–705. doi:10.1534/genetics.105.055152. PMC 1602071. PMID 16582438.
This article incorporates text from the public domain Pfam and InterPro: IPR021627

Further reading[edit]