MFN1

MFN1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1T3J
Identifiers
Aliases	MFN1, hfzo1, hfzo2, mitofusin 1
External IDs	OMIM: 608506; MGI: 1914664; HomoloGene: 11481; GeneCards: MFN1; OMA:MFN1 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	179,394,936 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	32,633,388 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; Achilles tendon; ; body of pancreas; ; gastric mucosa; ; epithelium of colon; ; right hemisphere of cerebellum; ; right uterine tube; ; right auricle; ; skin of leg; ; canal of the cervix;
	Top expressed in
	myocardium of ventricle; ; digastric muscle; ; right ventricle; ; cardiac muscle tissue of left ventricle; ; extraocular muscle; ; soleus muscle; ; extensor digitorum longus muscle; ; muscle of thigh; ; thoracic diaphragm; ; sternocleidomastoid muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding; GTP binding; protein binding; hydrolase activity; GTPase activity;
Cellular component	cytoplasm; mitochondrial outer membrane; mitochondrion; membrane; integral component of mitochondrial outer membrane; outer mitochondrial membrane protein complex; integral component of membrane; intrinsic component of mitochondrial outer membrane;
Biological process	mitochondrial fusion; macroautophagy; GTP metabolic process; mitochondrion localization;
	Sources:Amigo / QuickGO
Orthologs
	55669
	67414
	ENSG00000171109
	ENSMUSG00000027668
	Q8IWA4
	Q811U4
	NM_017927; NM_033540
	NM_024200
	NP_284941
	NP_077162
	Wikidata
View/Edit Human	View/Edit Mouse

Mitofusin-1 is a protein that in humans is encoded by the MFN1 gene.^[5]^[6]^[7]

The protein encoded by this gene is a mediator of mitochondrial fusion. This protein and mitofusin 2 are homologs of the Drosophila protein fuzzy onion (Fzo). They are mitochondrial membrane proteins that interact with each other to facilitate mitochondrial targeting.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000171109 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027668 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Adams MD, Kerlavage AR, Fields C, Venter JC (Sep 1993). "3,400 new expressed sequence tags identify diversity of transcripts in human brain". Nat Genet. 4 (3): 256–67. doi:10.1038/ng0793-256. PMID 8358434. S2CID 20528590.
^ Santel A, Fuller MT (Feb 2001). "Control of mitochondrial morphology by a human mitofusin". J Cell Sci. 114 (Pt 5): 867–74. doi:10.1242/jcs.114.5.867. PMID 11181170.
^ ^a ^b "Entrez Gene: MFN1 mitofusin 1".

Pawlikowska P, Orzechowski A (2007). "[Role of transmembrane GTPases in mitochondrial morphology and activity]". Postepy Biochem. 53 (1): 53–9. PMID 17718388.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Hales KG, Fuller MT (1997). "Developmentally regulated mitochondrial fusion mediated by a conserved, novel, predicted GTPase". Cell. 90 (1): 121–9. doi:10.1016/S0092-8674(00)80319-0. PMID 9230308. S2CID 15162087.
Chung JG, Yeh KT, Wu SL, et al. (2002). "Novel transmembrane GTPase of non-small cell lung cancer identified by mRNA differential display". Cancer Res. 61 (24): 8873–9. PMID 11751411.
Rojo M, Legros F, Chateau D, Lombès A (2003). "Membrane topology and mitochondrial targeting of mitofusins, ubiquitous mammalian homologs of the transmembrane GTPase Fzo". J. Cell Sci. 115 (Pt 8): 1663–74. doi:10.1242/jcs.115.8.1663. PMID 11950885.
Legros F, Lombès A, Frachon P, Rojo M (2003). "Mitochondrial Fusion in Human Cells Is Efficient, Requires the Inner Membrane Potential, and Is Mediated by Mitofusins". Mol. Biol. Cell. 13 (12): 4343–54. doi:10.1091/mbc.E02-06-0330. PMC 138638. PMID 12475957.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Santel A, Frank S, Gaume B, et al. (2004). "Mitofusin-1 protein is a generally expressed mediator of mitochondrial fusion in mammalian cells". J. Cell Sci. 116 (Pt 13): 2763–74. doi:10.1242/jcs.00479. PMID 12759376.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Cipolat S, Martins de Brito O, Dal Zilio B, Scorrano L (2004). "OPA1 requires mitofusin 1 to promote mitochondrial fusion". Proc. Natl. Acad. Sci. U.S.A. 101 (45): 15927–32. Bibcode:2004PNAS..10115927C. doi:10.1073/pnas.0407043101. PMC 528769. PMID 15509649.
Cartoni R, Léger B, Hock MB, et al. (2005). "Mitofusins 1/2 and ERRα expression are increased in human skeletal muscle after physical exercise". J. Physiol. 567 (Pt 1): 349–58. doi:10.1113/jphysiol.2005.092031. PMC 1474174. PMID 15961417.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000171109 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027668 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8358434-5] Adams MD, Kerlavage AR, Fields C, Venter JC (Sep 1993). "3,400 new expressed sequence tags identify diversity of transcripts in human brain". Nat Genet. 4 (3): 256–67. doi:10.1038/ng0793-256. PMID 8358434. S2CID 20528590.

[pmid11181170-6] Santel A, Fuller MT (Feb 2001). "Control of mitochondrial morphology by a human mitofusin". J Cell Sci. 114 (Pt 5): 867–74. doi:10.1242/jcs.114.5.867. PMID 11181170.

[entrez-7] "Entrez Gene: MFN1 mitofusin 1".

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[3]

[4]

[5]

[6]

[7]

References

Further reading