MGST2

From Wikipedia, the free encyclopedia
Jump to: navigation, search
MGST2
Identifiers
Aliases MGST2, GST2, MGST-II, microsomal glutathione S-transferase 2
External IDs MGI: 2448481 HomoloGene: 1811 GeneCards: MGST2
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001204366
NM_001204367
NM_001204368
NM_002413

NM_174995
NM_001310482

RefSeq (protein)

NP_001191295
NP_001191296
NP_001191297
NP_002404

n/a

Location (UCSC) Chr 4: 139.67 – 139.74 Mb Chr 3: 51.66 – 51.68 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Microsomal glutathione S-transferase 2 is an enzyme that in humans is encoded by the MGST2 gene.[3][4]

The MAPEG (Membrane-Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, several of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes a protein that catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Jakobsson PJ, Mancini JA, Ford-Hutchinson AW (Oct 1996). "Identification and characterization of a novel human microsomal glutathione S-transferase with leukotriene C4 synthase activity and significant sequence identity to 5-lipoxygenase-activating protein and leukotriene C4 synthase". J Biol Chem. 271 (36): 22203–10. doi:10.1074/jbc.271.36.22203. PMID 8703034. 
  4. ^ a b "Entrez Gene: MGST2 microsomal glutathione S-transferase 2". 

Further reading[edit]